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EPO erythropoietin [ Canis lupus familiaris (dog) ]

Gene ID: 404002, updated on 5-Mar-2024

Summary

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Official Symbol
EPOprovided by VGNC
Official Full Name
erythropoietinprovided by VGNC
Primary source
VGNC:VGNC:40422
See related
Ensembl:ENSCAFG00845001075
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See EPO in Genome Data Viewer
Location:
chromosome: 6
Exon count:
4
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (8928384..8930368, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (10698441..10700425, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (8940837..8942821, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (8780936..8782920, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (8759117..8761101, complement)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene EPH receptor B4 Neighboring gene zonadhesin Neighboring gene POP7 homolog, ribonuclease P/MRP subunit Neighboring gene GRB10 interacting GYF protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cholesterol is required for the polarized secretion of erythropoietin in Madin-Darby canine kidney cells. Maruyama M, et al. Arch Biochem Biophys, 2005 Jun 15. PMID 15916748
  2. Upregulation of erythropoietin receptor during postnatal and postpneumonectomy lung growth. Foster DJ, et al. Am J Physiol Lung Cell Mol Physiol, 2004 Dec. PMID 15286000
  3. Erythropoietin structure-function relationships: high degree of sequence homology among mammals. Wen D, et al. Blood, 1993 Sep 1. PMID 8364201

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. apical secretion of EPO involves a cholesterol-dependent mechanism probably not involving lipid rafts
    Title: Cholesterol is required for the polarized secretion of erythropoietin in Madin-Darby canine kidney cells.
  2. Developmental and compensatory lung growth involve paracrine erythropoietin signaling with parallel upregulation but differential processing of the erythropoietin receptor.
    Title: Upregulation of erythropoietin receptor during postnatal and postpneumonectomy lung growth.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables erythropoietin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
erythropoietin; LOW QUALITY PROTEIN: erythropoietin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    8928384..8930368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038667690.1 → XP_038523618.1  LOW QUALITY PROTEIN: erythropoietin

    UniProtKB/Swiss-Prot
    P33707, Q6PWU5
    Related
    ENSCAFP00845001467.1, ENSCAFT00845001862.1
    Conserved Domains (1) summary
    pfam00758
    Location:44 → 205
    EPO_TPO; Erythropoietin/thrombopoietin

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    8780936..8782920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038480397.1 → XP_038336325.1  LOW QUALITY PROTEIN: erythropoietin

    Conserved Domains (1) summary
    pfam00758
    Location:44 → 205
    EPO_TPO; Erythropoietin/thrombopoietin

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    8759117..8761101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038602984.1 → XP_038458912.1  LOW QUALITY PROTEIN: erythropoietin

    Conserved Domains (1) summary
    pfam00758
    Location:44 → 205
    EPO_TPO; Erythropoietin/thrombopoietin

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    8940837..8942821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038538855.1 → XP_038394783.1  LOW QUALITY PROTEIN: erythropoietin

    UniProtKB/Swiss-Prot
    P33707, Q6PWU5
    Conserved Domains (1) summary
    pfam00758
    Location:44 → 205
    EPO_TPO; Erythropoietin/thrombopoietin

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    10698441..10700425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038533714.1 → XP_038389642.1  LOW QUALITY PROTEIN: erythropoietin

    UniProtKB/Swiss-Prot
    P33707, Q6PWU5
    Conserved Domains (1) summary
    pfam00758
    Location:44 → 205
    EPO_TPO; Erythropoietin/thrombopoietin

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006646.1: Suppressed sequence

    Description
    NM_001006646.1: This RefSeq was removed because there were several differences (mismatches and/or insertions and/or deletions) compared to available sequence data.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33707.2 GenPept UniProtKB/Swiss-Prot:P33707

Gene LinkOut

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