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TGFB1 transforming growth factor beta 1 [ Canis lupus familiaris (dog) ]

Gene ID: 403998, updated on 5-Mar-2024

Summary

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Gene symbol
TGFB1
Gene description
transforming growth factor beta 1
See related
Ensembl:ENSCAFG00845002395
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (113227503..113242482)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (112032673..112048407)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (113413527..113429277)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (112787896..112803616)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (112420232..112435965)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 91 Neighboring gene B9 domain containing 2 Neighboring gene coiled-coil domain containing 97 Neighboring gene uncharacterized LOC119867534 Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Apoptosis and abundance of Bcl-2 family and transforming growth factor β1 signaling proteins in canine myxomatous mitral valves. Surachetpong S, et al. J Vet Cardiol, 2013 Sep. PMID 23816827
  2. Interactions between TGFβ1 and cyclic strain in modulation of myofibroblastic differentiation of canine mitral valve interstitial cells in 3D culture. Waxman AS, et al. J Vet Cardiol, 2012 Mar. PMID 22386586, Free PMC Article
  3. Expression of TGFbeta1 in pulmonary vein stenosis after radiofrequency ablation in chronic atrial fibrillation of dogs. Li S, et al. Mol Biol Rep, 2009 Feb. PMID 17972164
  4. Role for TGF-beta in cyclosporine-induced modulation of renal epithelial barrier function. Feldman G, et al. J Am Soc Nephrol, 2007 Jun. PMID 17460148
  5. Cloning of a canine cDNA homologous to the human transforming growth factor-beta 1-encoding gene. Manning AM, et al. Gene, 1995 Apr 3. PMID 7721110

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of smad7 inhibits the TGF-beta/Smad signaling pathway and EMT in NPHP1-defective MDCK cells.
    Title: Overexpression of smad7 inhibits the TGF-β/Smad signaling pathway and EMT in NPHP1-defective MDCK cells.
  2. Hypoxia disrupts polarized epithelial morphogenesis of MDCK cells in a HIF1alpha-dependent manner by modulating the transforming growth factor-beta1 signaling pathway.
    Title: BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia.
  3. he results of the present study suggested that USAG1 may be involved in the EMT process of MDCK cells induced by TGFbeta1, and febuxostat inhibited EMT by activating the Smad1/5/8 signaling pathway via downregulating the expression of USAG1 in MDCK cells.
    Title: Febuxostat inhibits TGF‑β1‑induced epithelial‑mesenchymal transition via downregulation of USAG‑1 expression in Madin‑Darby canine kidney cells in vitro.
  4. Results suggested that CD61 (integrin-beta3) could induce canine adipose-derived mesenchymal stem cells (cADMSCs) to differentiate into primordial germ cell (PGC)-like cells by relying on the activation of transforming growth factor beta (TGF-beta) pathway.
    Title: CD61 promotes the differentiation of canine ADMSCs into PGC-like cells through modulation of TGF-β signaling.
  5. obstructive sleep apnea can accelerate the progression of pulmonary remodeling through TGF-beta/miR-185/CoLA1 signaling
    Title: Chronic obstructive sleep apnea accelerates pulmonary remodeling via TGF-β/miR-185/CoLA1 signaling in a canine model.
  6. TGFbeta1 signaling through the canonical SMAD pathway is increased in myxomatous mitral valves, but does not apparently mediate interstitial cell apoptosis in canine MMVD.
    Title: Apoptosis and abundance of Bcl-2 family and transforming growth factor β1 signaling proteins in canine myxomatous mitral valves.
  7. IL-6 markedly decreased the nuclear concentration of a TGF-beta signaling transducer, Smad 2/3.
    Title: IL-6 restores dendritic cell maturation inhibited by tumor-derived TGF-β through interfering Smad 2/3 nuclear translocation.
  8. celastrol downregulates Snail expression, thereby inhibiting TGF-beta1-induced EMT in MDCK and A549 cells
    Title: Celastrol inhibits TGF-β1-induced epithelial-mesenchymal transition by inhibiting Snail and regulating E-cadherin expression.
  9. Ostectomy healing with or without platelet-rich plasma as indicated by radiography and expression of PDGF and TGF-beta expression are reported.
    Title: Healing and expression of growth factors (TGF-β and PDGF) in canine radial ostectomy gap containing platelet-rich plasma.
  10. This study tested the hypothesis that cyclic strain and TGFbeta1 interact to modify mitral valve interstitial cell phenotype in 3D culture.
    Title: Interactions between TGFβ1 and cyclic strain in modulation of myofibroblastic differentiation of canine mitral valve interstitial cells in 3D culture.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables type II transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables type III transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transforming growth factor beta-1 proprotein
Names
TGF-beta-1
transforming growth factor, beta 1 (Camurati-Engelmann disease)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    113227503..113242482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038656896.1 → XP_038512824.1  transforming growth factor beta-1 proprotein isoform X2

    UniProtKB/Swiss-Prot
    P54831
    UniProtKB/TrEMBL
    A0A8C0KNK1, A0A8C0QN79, A0A8I3MFB3
    Related
    ENSCAFP00845003405.1, ENSCAFT00845004265.1
    Conserved Domains (2) summary
    cd19384
    Location:292 → 390
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30 → 261
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038656895.1 → XP_038512823.1  transforming growth factor beta-1 proprotein isoform X1

    UniProtKB/Swiss-Prot
    P54831
    Conserved Domains (2) summary
    cd19384
    Location:293 → 391
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30 → 262
    TGFb_propeptide; TGF-beta propeptide

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    112787896..112803616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038468068.1 → XP_038323996.1  transforming growth factor beta-1 proprotein isoform X1

    Conserved Domains (2) summary
    cd19384
    Location:293 → 391
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30 → 262
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038468069.1 → XP_038323997.1  transforming growth factor beta-1 proprotein isoform X2

    Conserved Domains (2) summary
    cd19384
    Location:292 → 390
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30 → 261
    TGFb_propeptide; TGF-beta propeptide

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    112420232..112435965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038593078.1 → XP_038449006.1  transforming growth factor beta-1 proprotein isoform X1

    Conserved Domains (2) summary
    cd19384
    Location:293 → 391
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30 → 262
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038593079.1 → XP_038449007.1  transforming growth factor beta-1 proprotein isoform X2

    Conserved Domains (2) summary
    cd19384
    Location:292 → 390
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30 → 261
    TGFb_propeptide; TGF-beta propeptide

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    113413527..113429277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038528805.1 → XP_038384733.1  transforming growth factor beta-1 proprotein isoform X1

    UniProtKB/Swiss-Prot
    P54831
    Conserved Domains (2) summary
    cd19384
    Location:293 → 391
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30 → 262
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038528806.1 → XP_038384734.1  transforming growth factor beta-1 proprotein isoform X2

    UniProtKB/Swiss-Prot
    P54831
    UniProtKB/TrEMBL
    A0A8C0KNK1, A0A8C0QN79, A0A8I3MFB3
    Conserved Domains (2) summary
    cd19384
    Location:292 → 390
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30 → 261
    TGFb_propeptide; TGF-beta propeptide

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    112032673..112048407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038444997.1 → XP_038300925.1  transforming growth factor beta-1 proprotein isoform X1

    UniProtKB/Swiss-Prot
    P54831
    Conserved Domains (2) summary
    cd19384
    Location:293 → 391
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30 → 262
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038445068.1 → XP_038300996.1  transforming growth factor beta-1 proprotein isoform X2

    UniProtKB/Swiss-Prot
    P54831
    UniProtKB/TrEMBL
    A0A8C0KNK1, A0A8C0QN79, A0A8I3MFB3
    Conserved Domains (2) summary
    cd19384
    Location:292 → 390
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30 → 261
    TGFb_propeptide; TGF-beta propeptide

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003309.1: Suppressed sequence

    Description
    NM_001003309.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54831.1 GenPept UniProtKB/Swiss-Prot:P54831

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