IL6 interleukin 6 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: IL6provided by VGNC
Official Full Name: interleukin 6provided by VGNC
Primary source: VGNC:VGNC:41992
See related: Ensembl:ENSCAFG00845008825
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: IL-6
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	14	NC_051818.1 (36398579..36402833)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	14	NC_006596.4 (36015351..36019602)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	14	NC_049235.1 (36553276..36557530)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	14	NC_049274.1 (36519712..36523966)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	14	NC_049755.1 (36216365..36220619)

Chromosome 14 - NC_051818.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An increase in ventricular dimension is accompanied by increases in AQP4 and IL-6 concentrations in the CSF of dogs with idiopathic communicating hydrocephalus. All were greatly reduced or normalised after shunt treatment. Therefore AQP4 and IL-6 in CSF can be indicators of ventriculomegaly, of cellular damage, and of improvement after the treatment of hydrocephalus.
Title: Increased CSF aquaporin-4, and interleukin-6 levels in dogs with idiopathic communicating internal hydrocephalus and a decrease after ventriculo-peritoneal shunting.
The results of this study suggest that IL-6 is a useful prognostic marker for canine critical care patients with acute internal disease.
Title: Interleukin-6 as a prognostic marker in dogs in an intensive care unit.
This diminished TNF-alpha, IL-6 and iNOS expression, and NO production was in parallel to the respective decreased NF-kappaB p65 protein nuclear translocation in the LPS-activated canine PBMCs pretreated with 25 microM and 50 microM propofol.
Title: Propofol attenuates LPS-induced tumor necrosis factor-α, interleukin-6 and nitric oxide expression in canine peripheral blood mononuclear cells possibly through down-regulation of nuclear factor (NF)-κB activation.
Release of interleukin-6 and substance P may initiate proinflammatory effects leading to development of persistent pain in dogs with syringomyelia.
Title: A potential role for substance P and interleukin-6 in the cerebrospinal fluid of Cavalier King Charles Spaniels with neuropathic pain.
The etiology of blindness in dogs with pituitary dependent hypercortisolism, including the role of adiponectin, interleukin 6, insulin, and nitric oxide, is reported.
Title: Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism.
There was no association between IL6 variants and periodontal disease in dogs.
Title: Detection and characterization of interleukin-6 gene variants in Canis familiaris: association studies with periodontal disease.
These findings suggest that IL-6 secretion during acute urinary tract infection may serve a dual biological role by initiating the inflammatory response while also repairing urothelial defenses.
Title: Autocrine effects of interleukin-6 mediate acute-phase proinflammatory and tissue-reparative transcriptional responses of canine bladder mucosa.
Adipose tissue-derived mesenchymal stem cells expressed the mRNA of transforming growth factor beta (TGF-beta), IL-6, IL-8, CCL2, CCL5, VEGF,HGF, tissue inhibitor metalloproteinase-1/2, and cyclooxygenase-2 but not that of IL-10.
Title: Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells.
Plasma IL-6 concentration is predictive of outcome in canine systemic inflammatory response syndrome and sepsis and may be a valuable laboratory parameter for assessing critically ill dogs.
Title: Plasma interleukin-6 response is predictive for severity and mortality in canine systemic inflammatory response syndrome and sepsis.
Tumor-infiltrating lymphocytes isolated from regressing canine transmissible venereal tumor secrete high concentrations of IL-6 and antagonize the anti-lymphokine-activated killer activity of tumor cell transforming growth factor-beta 1.
Title: Tumor-infiltrating lymphocyte secretion of IL-6 antagonizes tumor-derived TGF-beta 1 and restores the lymphokine-activated killing activity.

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General gene information

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Markers

IL6 (e-PCR), detects polymorphism
- UniSTS:264075

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables interleukin-6 receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in T-helper 17 cell lineage commitment	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-6

Names: interleukin 6 (interferon, beta 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.