HSPB1 heat shock protein family B (small) member 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: HSPB1provided by VGNC
Official Full Name: heat shock protein family B (small) member 1provided by VGNC
Primary source: VGNC:VGNC:53534
See related: Ensembl:ENSCAFG00845004436
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: HSP27
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	6	NC_051810.1 (7307626..7309048)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	6	NC_006588.4 (9182749..9184173)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	6	NC_049227.1 (7403114..7404545)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	6	NC_049266.1 (7276667..7278079)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	6	NC_049747.1 (7239649..7241061)

Chromosome 6 - NC_051810.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data provide evidence that canine HSP27 overexpression can promote anchorage-independent growth, migration, and increased doxorubicin resistance in canine mammary tumor cells.
Title: Canine heat shock protein 27 promotes proliferation, migration, and doxorubicin resistance in the canine cell line DTK-F.
The usefulness of HSP27, HSP70, and TNF-alpha as biological markers for canine skin diseases was studied.
Title: Evaluation of HSP70, 27 and TNF-alpha expression [corrected] in different canine cutaneous and gland diseases.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein folding chaperone	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein refolding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to heat	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: heat shock protein beta-1

Names: canine mammary tumor; heat shock protein 27 kDa beta-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003295.2 → NP_001003295.2 heat shock protein beta-1

Status: VALIDATED

Source sequence(s)

JAAUVH010000065

UniProtKB/TrEMBL

A0A097HUC9, A0A8C0MMM4, A0A8P0NFA6, F1PYE3

Related

ENSCAFP00845006274.1, ENSCAFT00845007970.1

Conserved Domains (1) summary

cd06475
Location:85 → 170

ACD_HspB1_like; Alpha crystallin domain (ACD) found in mammalian small (s)heat shock protein (Hsp)-27 (also denoted HspB1 in human) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally ...