IL12B interleukin 12B [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: IL12Bprovided by VGNC
Official Full Name: interleukin 12Bprovided by VGNC
Primary source: VGNC:VGNC:41933
See related: Ensembl:ENSCAFG00845001277
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	4	NC_051808.1 (51613430..51629329)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	4	NC_006586.4 (51076678..51086695)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	4	NC_049225.1 (52069793..52079810)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	4	NC_049264.1 (51447354..51457365)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	4	NC_049745.1 (51553170..51563187)

Chromosome 4 - NC_051808.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparison of serum cytokine concentrations between healthy dogs and canine osteosarcoma patients at the time of diagnosis.
Title: Comparison of serum cytokine concentrations between healthy dogs and canine osteosarcoma patients at the time of diagnosis.
Data indicate that the Leishmania braziliensis antigens plus saponin (LBSap) vaccine induced high levels of IL-12, IL-10, CCL4, CCL5 and CXCL8 expression within 48 hours.
Title: Dogs immunized with LBSap vaccine displayed high levels of IL-12 and IL-10 cytokines and CCL4, CCL5 and CXCL8 chemokines in the dermis.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immunoglobulin mediated immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-12 subunit beta

Names: CLMF p40; IL-12 subunit p40; IL-12B; cytotoxic lymphocyte maturation factor 40 kDa subunit; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 p40 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003292.1 → NP_001003292.1 interleukin-12 subunit beta precursor

See identical proteins and their annotated locations for NP_001003292.1

Status: PROVISIONAL

Source sequence(s)

U49100

UniProtKB/Swiss-Prot

Q28268

UniProtKB/TrEMBL

A0A8C0Q621

Conserved Domains (3) summary

smart00408
Location:42 → 90

IGc2; Immunoglobulin C-2 Type

cd00063
Location:236 → 326

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam10420
Location:126 → 217

IL12p40_C; Cytokine interleukin-12p40 C-terminus

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051808.1 Reference ROS_Cfam_1.0

Range

51613430..51629329

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038662232.1 → XP_038518160.1 interleukin-12 subunit beta isoform X1

UniProtKB/TrEMBL

A0A8C0Q621, A0A8I3MFA7, A0A8P0NIM9

Related

ENSCAFP00845001755.1, ENSCAFT00845002222.1

Conserved Domains (4) summary

smart00408
Location:42 → 90

IGc2; Immunoglobulin C-2 Type

cd00063
Location:236 → 326

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam10420
Location:128 → 217

IL12p40_C; Cytokine interleukin-12p40 C-terminus

cd00096
Location:44 → 50

Ig; Ig strand B [structural motif]