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GNAS GNAS complex locus [ Canis lupus familiaris (dog) ]

Gene ID: 403943, updated on 5-Mar-2024

Summary

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Official Symbol
GNASprovided by VGNC
Official Full Name
GNAS complex locusprovided by VGNC
Primary source
VGNC:VGNC:54650
See related
Ensembl:ENSCAFG00845013733
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
gnas1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (44469667..44524884)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (42885440..42905085)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (44387669..44407318)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (43609062..43628699)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (43727472..43747093)

Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene aminopeptidase like 1 Neighboring gene uncharacterized LOC102153173 Neighboring gene uncharacterized LOC119865708 Neighboring gene phosphorylated adapter RNA export protein-like Neighboring gene negative elongation factor complex member C/D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs. Yu Y, et al. BMC Genomics, 2022 Sep 23. PMID 36151521, Free PMC Article
  2. Exclusion of a T>C sequence variant in exon 7 of the canine G(alphas) gene (GNAS1) as a causal gene for liver cancer. Dudenbostel KJ, et al. Anim Genet, 2009 Oct. PMID 19422361
  3. Alternative promoter and 5' exon generate a novel Gs alpha mRNA. Ishikawa Y, et al. J Biol Chem, 1990 May 25. PMID 2111318

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs.
    Title: A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs.
  2. Exclusion of a T>C sequence variant in exon 7 of the canine G(alphas) gene (GNAS1) as a causal gene for liver cancer.
    Title: Exclusion of a T>C sequence variant in exon 7 of the canine G(alphas) gene (GNAS1) as a causal gene for liver cancer.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables D1 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables beta-2 adrenergic receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables corticotropin-releasing hormone receptor 1 binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mu-type opioid receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sensory perception of chemical stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide-binding protein G(s) subunit alpha
Names
GTP-binding regulatory protein alpha subunit exon 1
adenylate cyclase-stimulating G alpha protein
guanine nucleotide binding protein alpha subunit
guanine nucleotide binding protein, alpha stimulating activity polypeptide 1
stimulatory GTP binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003263.1 → NP_001003263.1  guanine nucleotide-binding protein G(s) subunit alpha

    See identical proteins and their annotated locations for NP_001003263.1

    Status: PROVISIONAL

    Source sequence(s)
    Z12168
    UniProtKB/Swiss-Prot
    P63091
    UniProtKB/TrEMBL
    A0A8C0LD06, A0A8C0P585, A0A8I3NFU9
    Related
    ENSCAFP00845019485.1, ENSCAFT00845024770.1
    Conserved Domains (1) summary
    cd00066
    Location:41 → 388
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051828.1 Reference ROS_Cfam_1.0

    Range
    44469667..44524884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038432802.1 → XP_038288730.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8P0TNP4
    Conserved Domains (3) summary
    cd00066
    Location:629 → 961
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    PHA03247
    Location:29 → 386
    PHA03247; large tegument protein UL36; Provisional
    cd22249
    Location:587 → 621
    UDM1_RNF168_RNF169-like; UDM1 (ubiquitin-dependent DSB recruitment module 1) found in RING finger proteins RNF168, RNF169 and similar proteins

  2. XM_038432801.1 → XP_038288729.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0NMX5, A0A8I3NR61, A0A8P0TNP4
    Related
    ENSCAFP00845019414.1, ENSCAFT00845024669.1
    Conserved Domains (3) summary
    cd00066
    Location:629 → 976
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    PHA03247
    Location:29 → 386
    PHA03247; large tegument protein UL36; Provisional
    cd22249
    Location:587 → 621
    UDM1_RNF168_RNF169-like; UDM1 (ubiquitin-dependent DSB recruitment module 1) found in RING finger proteins RNF168, RNF169 and similar proteins

  3. XM_038432808.1 → XP_038288736.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X8

    UniProtKB/TrEMBL
    A0A8C0P585, A0A8I3NFU9
    Conserved Domains (1) summary
    cd00066
    Location:1 → 329
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  4. XM_038432807.1 → XP_038288735.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X7

    UniProtKB/TrEMBL
    A0A8C0P585, A0A8I3NFU9
    Conserved Domains (1) summary
    cd00066
    Location:1 → 330
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  5. XM_038432803.1 → XP_038288731.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C0P585, A0A8I3NFU9
    Conserved Domains (1) summary
    cd00066
    Location:41 → 389
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  6. XM_038432804.1 → XP_038288732.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A8C0P585, A0A8I3NFU9
    Conserved Domains (1) summary
    cd00066
    Location:41 → 374
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  7. XM_038432805.1 → XP_038288733.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X5

    UniProtKB/TrEMBL
    A0A8C0P585, A0A8I3NFU9
    Conserved Domains (1) summary
    cd00066
    Location:41 → 373
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  8. XM_038432806.1 → XP_038288734.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X6

    UniProtKB/TrEMBL
    A0A8C0P585, A0A8I3NFU9
    Related
    ENSCAFP00845019386.1, ENSCAFT00845024641.1
    Conserved Domains (1) summary
    cd00066
    Location:8 → 349
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049284.1 Alternate UMICH_Zoey_3.1

    Range
    43609062..43628699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

    Range
    43727472..43747093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

    Range
    44387669..44407318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    42885440..42905085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63091.1 GenPept UniProtKB/Swiss-Prot:P63091

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