MMP9 matrix metallopeptidase 9 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MMP9provided by VGNC
Official Full Name: matrix metallopeptidase 9provided by VGNC
Primary source: VGNC:VGNC:43290
See related: Ensembl:ENSCAFG00845017615
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	24	NC_051828.1 (33984592..33991450)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	24	NC_006606.4 (32801110..32807958)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	24	NC_049245.1 (33897331..33904192)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	24	NC_049284.1 (33242837..33249697)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	24	NC_049765.1 (33358136..33364990)

Chromosome 24 - NC_051828.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It was concluded that NGAL and MMP9 are ubiquitously expressed in canine mammary epithelial cells in normal and cancerous status; however, the NGAL/MMP9 complex exclusively presents in mammary tissues and urine of dogs with tumours.
Title: Expression and the molecular forms of neutrophil gelatinase-associated lipocalin and matrix metalloproteinase 9 in canine mammary tumours.
These results were not able to clearly confirm the influence of MMPs on the proliferation and apoptotic activity of canine lymphoma cells.
Title: Immunohistochemical assessment of metalloproteinases MMP2 and MMP9 expression in canine various subtypes of lymphomas in relation with proliferative and apoptotic markers.
Studied expression of matrix metallopeptidase 9 and CD31 expression during wound healing under Negative Pressure Wound Therapy in dogs.
Title: Histomorphometric evaluation of MMP-9 and CD31 expression during healing under Negative Pressure Wound Therapy in dogs.
The parasite load, intensity of inflammation, and production of MMP-2 (latent) and MMP-9 (active and latent) were higher in the ear and muzzle regions.
Title: Expression of matrix metalloproteinase-2 and metalloproteinase-9 in the skin of dogs with visceral leishmaniasis.
MMP-2 and MMP-9 expression extended to the implantative endometrium, including deep glandular areas. MMP-9 is well expressed in the early canine placenta, but it is not active.
Title: Differential expression and activity of matrix metalloproteinases 2 and 9 in canine early placenta.
expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 was found in canine transmissible venereal tumors
Title: Immunocharacterization of matrix metalloproteinase-2 and matrix metalloproteinase-9 in canine transmissible venereal tumors.
Immunohistochemical Expression of CCR2, CSF1R and MMP9 in Canine Inflammatory Mammary Carcinomas
Title: Immunohistochemical Expression of CCR2, CSF1R and MMP9 in Canine Inflammatory Mammary Carcinomas.
Lymphoma dogs showed higher act-MMP-9 and VEGF, and lower TGF-beta than controls, and a positive correlation between act-MMP-9 and VEGF.
Title: VEGF and MMP-9: biomarkers for canine lymphoma.
This study suggests that MMP-2 and MMP-9 may take part in the brain inflammatory changes of subacute distemper leukoencephalitis.
Title: Zymographic patterns of MMP-2 and MMP-9 in the CSF and cerebellum of dogs with subacute distemper leukoencephalitis.
The relationship between the cerebrospinal fluid (CSF) levels of cartilage oligomeric matrix protein is related to disease severity, prognosis and matrix metalloproteinase-9 activity of the CSF in dogs with intervertebral disc herniation is reported.
Title: Analysis of cartilage oligomeric matrix protein and matrix metalloproteinase-9 in cerebrospinal fluid of miniature dachshund with intervertebral disc herniation.

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General gene information

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Markers

MMP9 (e-PCR), detects polymorphism
- UniSTS:505910

MMP9 (e-PCR), detects polymorphism
- UniSTS:264112

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: matrix metalloproteinase-9

Names: 92 kDa gelatinase; 92 kDa type IV collagenase; GELB; MMP-9; gelatinase B; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9; type IV collagenase MMP-9

NP_001003219.1

EC 3.4.24.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003219.2 → NP_001003219.1 matrix metalloproteinase-9 precursor

See identical proteins and their annotated locations for NP_001003219.1

Status: PROVISIONAL

Source sequence(s)

AF169244

UniProtKB/Swiss-Prot

O18733, O19130

UniProtKB/TrEMBL

Q71U09

Related

ENSCAFP00845024511.1, ENSCAFT00845031310.1

Conserved Domains (4) summary

smart00059
Location:340 → 388

FN2; Fibronectin type 2 domain

cd00094
Location:511 → 701

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:115 → 444

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:115 → 444

Peptidase_M10; Matrixin