HTR2B 5-hydroxytryptamine receptor 2B [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: HTR2Bprovided by VGNC
Official Full Name: 5-hydroxytryptamine receptor 2Bprovided by VGNC
Primary source: VGNC:VGNC:41827
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	25	NC_051829.1 (43299319..43313380, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	25	NC_006607.4 (43602608..43616665, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	25	NC_049246.1 (43226286..43240447, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	25	NC_049285.1 (43227978..43242026, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	25	NC_049766.1 (43070901..43084964, complement)

Chromosome 25 - NC_051829.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There was a positive association between gene expression of the 5-HT2BR in the mitral valve and myocardium and clinical presence of canine myxomatous mitral valve disease. The same association was not found for the 5-HT2AR.
Title: Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease.
Myocardium of control dogs showed constitutive 5-HTR2B mRNA expression. In dogs with dilated cardiomyopathy, 5-HTR2B mRNA values were significantly greater than in all other groups, with highest levels of expression in the left ventricle and right atrium.
Title: The potential role of myocardial serotonin receptor 2B expression in canine dilated cardiomyopathy.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables neurotransmitter receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heart development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of behavior	IEA Inferred from Electronic Annotation more info	PubMed
involved_in smooth muscle contraction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 2B

Names: 5HT2B receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024633.1 → NP_001019804.1 5-hydroxytryptamine receptor 2B

See identical proteins and their annotated locations for NP_001019804.1

Status: PROVISIONAL

Source sequence(s)

AY832859

UniProtKB/TrEMBL

A0A8C0LJH8, A0A8C0TKW5, Q50DZ8

Conserved Domains (2) summary

pfam00001
Location:70 → 379

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:70 → 192

7tm_4; Olfactory receptor