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Rpn10 Regulatory particle non-ATPase 10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40388, updated on 5-May-2024

Summary

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Official Symbol
Rpn10provided by FlyBase
Official Full Name
Regulatory particle non-ATPase 10provided by FlyBase
Primary source
FLYBASE:FBgn0015283
Locus tag
Dmel_CG7619
See related
AllianceGenome:FB:FBgn0015283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
5SA; 7619; CG7619; Dmel\CG7619; DmS5a; dRpn10; mu-54; p54; pros54; Pros54; rpn10; Rpn10/p54; S5a; S5A
Summary
Enables ubiquitin conjugating enzyme binding activity and zinc ion binding activity. Involved in mitotic sister chromatid segregation and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Part of proteasome regulatory particle. Is expressed in adult head and organism. Orthologous to human PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
78D5-78D5; 3-47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21537000..21538582)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21530100..21531682)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Makorin 1 Neighboring gene pickpocket 5 Neighboring gene Cytochrome c oxidase subunit 8 Neighboring gene Vacuolar H[+] ATPase M9.7 subunit b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. STABILON, a Novel Sequence Motif That Enhances the Expression and Accumulation of Intracellular and Secreted Proteins. Rethi-Nagy Z, et al. Int J Mol Sci, 2022 Jul 25. PMID 35897744, Free PMC Article
  2. A gene-coexpression network for global discovery of conserved genetic modules. Stuart JM, et al. Science, 2003 Oct 10. PMID 12934013
  3. Mapping the ubiquitin-binding domains in the p54 regulatory complex subunit of the Drosophila 26S protease. Haracska L, et al. FEBS Lett, 1997 Jul 28. PMID 9256246
  4. Cloning and sequencing a non-ATPase subunit of the regulatory complex of the Drosophila 26S protease. Haracska L, et al. Eur J Biochem, 1995 Aug 1. PMID 7649173
  5. Tissue- and developmental stage-specific changes in the subcellular localization of the 26S proteasome in the ovary of Drosophila melanogaster. Adám G, et al. Gene Expr Patterns, 2004 May. PMID 15053983

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rpn10 is targeted for degradation by Ube3a.
    Title: Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10.
  2. Ubiquitylation of p54
    Title: Ubiquitylation of Drosophila p54/Rpn10/S5a regulates its interaction with the UBA-UBL polyubiquitin receptors.
  3. S5a/Rpn10/p54 deletion caused larval-pupal polyphasic lethality, multiple mitotic defects, the accumulation of higher multimers of ubiquitinated proteins and a huge accumulation of defective 26S proteasome particles.
    Title: Deletion of proteasomal subunit S5a/Rpn10/p54 causes lethality, multiple mitotic defects and overexpression of proteasomal genes in Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, base subcomplex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
regulatory particle non-ATPase 10
Names
54 kda mu particle subunit of 26S protease
CG7619-PA
CG7619-PB
Rpn10-PA
Rpn10-PB
proteasome 54kD subunit
subunit S5a

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21537000..21538582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079480.3 → NP_524204.1  regulatory particle non-ATPase 10, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524204.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P55035, Q86R87, Q9V473
    UniProtKB/TrEMBL
    M9PIG8
    Related
    FBpp0078024
    Conserved Domains (1) summary
    cd01452
    Location:1 → 187
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...

  2. NM_001275239.1 → NP_001262168.1  regulatory particle non-ATPase 10, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262168.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P55035, Q86R87, Q9V473
    UniProtKB/TrEMBL
    M9PIG8
    Conserved Domains (1) summary
    cd01452
    Location:1 → 187
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PIG8 M9PIG8
P55035.2 P55035

Gene LinkOut

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