ABCB1 ATP binding cassette subfamily B member 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ABCB1provided by VGNC
Official Full Name: ATP binding cassette subfamily B member 1provided by VGNC
Primary source: VGNC:VGNC:37431
See related: Ensembl:ENSCAFG00845007972
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: MDR1; p-gp
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	14	NC_051818.1 (13410127..13507439, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	14	NC_006596.4 (13216483..13313885, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	14	NC_049235.1 (13622793..13720201, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	14	NC_049274.1 (13613256..13710576, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	14	NC_049755.1 (13339096..13436445, complement)

Chromosome 14 - NC_051818.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MDR1 Inhibition Reverses Doxorubicin-Resistance in Six Doxorubicin-Resistant Canine Prostate and Bladder Cancer Cell Lines.
Title: MDR1 Inhibition Reverses Doxorubicin-Resistance in Six Doxorubicin-Resistant Canine Prostate and Bladder Cancer Cell Lines.
The most frequently affected breeds for ABCB1-1Delta mutation are the collie, Australian shepherd, white Swiss shepherd and Shetland sheepdog. As the mutation is associated with an increased incidence of adverse reactions to commonly used pharmaceuticals, veterinarians need to be aware of the breeds at most risk of carrying this mutation and consider testing these individuals prior to administering these medications
Title: Breed is associated with the ABCB1-1Δ mutation in Australian dogs.
A multicentre retrospective, case-control study was conducted to investigate associations between ABCB1 c.-6-180T>G, clinical variables, and refractoriness in a multi-breed population of dogs with refractory idiopathic epilepsy. A secondary aim was to evaluate the possible involvement of the ABCB1 c.-6-180T>G single nucleotide variation in this population.
Title: ABCB1 c.-6-180T>G polymorphism and clinical risk factors in a multi-breed cohort of dogs with refractory idiopathic epilepsy.
A statistically significant correlation between distinct canine breeds and the frequency of ABCB1 polymorphisms was observed in tissue DNA samples from canine mammary tumors. Additional studies comprising a number of samples expressing the ABCB1 gene from healthy dogs, with advanced age and from different breeds, will be necessary to confirm the association of ABCB1polymorphisms and the development of mammary tumors.
Title: Could polymorphisms in ABCB1 gene represent a genetic risk factor for the development of mammary tumors in dogs?
These results demonstrate the potential negative impact on estimates of drug effectiveness and toxicity, especially for P-gp substrates that do not exhibit Central Nervous System toxicities.
Title: Impact of ABCB1 genotype in Collies on the pharmacokinetics of R- and S-fexofenadine.
Permeability glycoprotein immunohistochemistry was evaluated in dogs with multicentric lymphoma treated with combined antineoplastic drug regimens.
Title: Evaluation of Pgp (MDR1) immunohistochemistry in canine lymphoma - prognostic and clinical aspects.
Malignant and invasive tumours were more likely to express PGP and/or BCRP in luminal and stromal components and evaluation of these markers could provide valuable information for the identification of tumours characterized by an aggressive and chemoresistant phenotype.
Title: Immunohistochemical Expression of P-glycoprotein and Breast Cancer Resistance Protein in Canine Mammary Hyperplasia, Neoplasia and Supporting Stroma.
The genetics of the MDR1 mutation that causes hypersensitivity to macrocyclic lactones was studied in predisposed dog breeds in multiple European countries.
Title: The prevalence of ABCB1:c.227_230delATAG mutation in affected dog breeds from European countries.
In ABCB1 mut/mut dogs acepromazine dose rates should be reduced and careful monitoring performed during sedation.
Title: The Effect of the Canine ABCB1-1Δ Mutation on Sedation after Intravenous Administration of Acepromazine.
Specific efflux mediated by hPGP or hBCRP can be determined with MDCKII cells where cPgp has been knocked out by zinc finger nucleases.
Title: Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ATP-dependent translocase ABCB1

Names: multidrug resistance p-glycoprotein

NP_001003215.2

EC 7.6.2.2

XP_038541840.1

EC 7.6.2.2

XP_038541841.1

EC 7.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003215.2 → NP_001003215.2 ATP-dependent translocase ABCB1

Status: VALIDATED

Source sequence(s)

AF536758, DN877923, DQ068953

UniProtKB/TrEMBL

A0A8C0L6Y9, A0A8C0MHY8, C0KKU9, F1PH01, Q4PLA8, Q6PSM2

Related

ENSCAFP00845011318.1, ENSCAFT00845014608.1

Conserved Domains (1) summary

PTZ00265
Location:48 → 1269

PTZ00265; multidrug resistance protein (mdr1); Provisional

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051818.1 Reference ROS_Cfam_1.0

Range

13410127..13507439 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038685912.1 → XP_038541840.1 ATP-dependent translocase ABCB1 isoform X1

UniProtKB/TrEMBL

A0A8C0L6Y9, A0A8C0MHY8, C0KKU9, F1PH01, Q4PLA8, Q6PSM2

Related

ENSCAFP00845011123.1, ENSCAFT00845014360.1

Conserved Domains (1) summary

PTZ00265
Location:48 → 1269

PTZ00265; multidrug resistance protein (mdr1); Provisional
XM_038685913.1 → XP_038541841.1 ATP-dependent translocase ABCB1 isoform X2

UniProtKB/TrEMBL

A0A8C0L6P1

Conserved Domains (1) summary

PTZ00265
Location:10 → 1231

PTZ00265; multidrug resistance protein (mdr1); Provisional