U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ADCY5 adenylate cyclase 5 [ Canis lupus familiaris (dog) ]

Gene ID: 403859, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ADCY5provided by VGNC
Official Full Name
adenylate cyclase 5provided by VGNC
Primary source
VGNC:VGNC:37622
See related
Ensembl:ENSCAFG00845024171
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 33
Exon count:
25
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 33 NC_051837.1 (26577319..26724145, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 33 NC_006615.4 (26367988..26513164, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 33 NC_049254.1 (26977815..27020671, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 33 NC_049293.1 (26374397..26519530, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 33 NC_049774.1 (26418883..26564205, complement)

Chromosome 33 - NC_051837.1Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase family A member 5 Neighboring gene SEC22 homolog A, vesicle trafficking protein Neighboring gene uncharacterized LOC119867337 Neighboring gene uncharacterized LOC119867339 Neighboring gene uncharacterized LOC119867338 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene uncharacterized LOC111093817 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. In vivo generation of an adenylylcyclase isoform with a half-molecule motif. Katsushika S, et al. J Biol Chem, 1993 Feb 5. PMID 8428899
  2. Isolation and characterization of a novel cardiac adenylylcyclase cDNA. Ishikawa Y, et al. J Biol Chem, 1992 Jul 5. PMID 1618857
  3. Two-metal-Ion catalysis in adenylyl cyclase. Tesmer JJ, et al. Science, 1999 Jul 30. PMID 10427002
  4. Adenylyl cyclase type 5 protein expression during cardiac development and stress. Hu CL, et al. Am J Physiol Heart Circ Physiol, 2009 Nov. PMID 19734365, Free PMC Article
  5. Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s. Baragli A, et al. Cell Signal, 2008 Mar. PMID 18164588

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Generate transgenic mice overexpressing canine adenylyl cyclase 5.
    Title: Adenylyl cyclase type 5 protein expression during cardiac development and stress.
  2. Show that adenylyl cyclases 2 and 5 can form a functional heterodimeric complex in HEK293 cells and mouse myocardium.
    Title: Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
adenylate cyclase type 5
Names
ATP pyrophosphate-lyase 5
adenylate cyclase type V
adenylyl cyclase 5
adenylyl cyclase type V
ca(2+)-inhibitable adenylyl cyclase
NP_001161932.1
XP_038300498.1
XP_038300499.1
XP_038300500.1
XP_038300501.1
XP_038300502.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168460.1 → NP_001161932.1  adenylate cyclase type 5

    See identical proteins and their annotated locations for NP_001161932.1

    Status: PROVISIONAL

    Source sequence(s)
    M88649
    UniProtKB/Swiss-Prot
    P30803
    UniProtKB/TrEMBL
    A0A8C0NP47
    Related
    ENSCAFP00845033585.1, ENSCAFT00845042843.1
    Conserved Domains (3) summary
    pfam00211
    Location:1066 → 1260
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:1 → 461
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:671 → 763
    DUF1053; Domain of Unknown Function (DUF1053)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051837.1 Reference ROS_Cfam_1.0

    Range
    26577319..26724145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038444571.1 → XP_038300499.1  adenylate cyclase type 5 isoform X2

    UniProtKB/TrEMBL
    A0A8I3S4F1
    Conserved Domains (3) summary
    pfam00211
    Location:1135 → 1329
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:1 → 461
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:671 → 763
    DUF1053; Domain of Unknown Function (DUF1053)

  2. XM_038444572.1 → XP_038300500.1  adenylate cyclase type 5 isoform X3

    UniProtKB/TrEMBL
    A0A8C0RL14, A0A8P0SH25
    Conserved Domains (3) summary
    pfam00211
    Location:1103 → 1297
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:1 → 461
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:671 → 763
    DUF1053; Domain of Unknown Function (DUF1053)

  3. XM_038444570.1 → XP_038300498.1  adenylate cyclase type 5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RL14, A0A8P0SH25
    Conserved Domains (3) summary
    pfam00211
    Location:1172 → 1366
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:1 → 461
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:671 → 763
    DUF1053; Domain of Unknown Function (DUF1053)

  4. XM_038444574.1 → XP_038300502.1  adenylate cyclase type 5 isoform X5

    Conserved Domains (3) summary
    pfam00211
    Location:832 → 1026
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:42 → 121
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:331 → 423
    DUF1053; Domain of Unknown Function (DUF1053)

  5. XM_038444573.1 → XP_038300501.1  adenylate cyclase type 5 isoform X4

    UniProtKB/TrEMBL
    A0A8C0TMF4
    Conserved Domains (3) summary
    pfam00211
    Location:463 → 636
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:1 → 461
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:671 → 763
    DUF1053; Domain of Unknown Function (DUF1053)

RNA

  1. XR_005306012.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049293.1 Alternate UMICH_Zoey_3.1

    Range
    26374397..26519530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049774.1 Alternate UNSW_CanFamBas_1.0

    Range
    26418883..26564205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049254.1 Alternate UU_Cfam_GSD_1.0

    Range
    26977815..27020671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006615.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    26367988..26513164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30803.2 GenPept UniProtKB/Swiss-Prot:P30803

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous