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MAPK14 mitogen-activated protein kinase 14 [ Canis lupus familiaris (dog) ]

Gene ID: 403856, updated on 5-Mar-2024

Summary

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Official Symbol
MAPK14provided by VGNC
Official Full Name
mitogen-activated protein kinase 14provided by VGNC
Primary source
VGNC:VGNC:42995
See related
Ensembl:ENSCAFG00845008249
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (5493681..5569596)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (5166000..5239239)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (5327755..5400924)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (5148463..5221682)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (5227753..5300687)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase A-like Neighboring gene solute carrier family 26 member 8 Neighboring gene uncharacterized LOC119874153 Neighboring gene uncharacterized LOC102153575 Neighboring gene mitogen-activated protein kinase 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. p38 mitogen-activated protein kinase expression and activation in smooth muscle. Hedges JC, et al. Am J Physiol, 1998 Aug. PMID 9688607
  2. Bcl-2 Phosphorylation by p38 MAPK: identification of target sites and biologic consequences. De Chiara G, et al. J Biol Chem, 2006 Jul 28. PMID 16714293
  3. Rho/ROCK-dependent pseudopodial protrusion and cellular blebbing are regulated by p38 MAPK in tumour cells exhibiting autocrine c-Met activation. Jia Z, et al. Biol Cell, 2006 Jun. PMID 16448388
  4. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Han J, et al. Science, 1994 Aug 5. PMID 7914033
  5. A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase. Blanco-Aparicio C, et al. J Cell Biol, 1999 Dec 13. PMID 10601328, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. as a mediator of SF- and Src-stimulated NF-kappaB activity. Finally, the Src/Rac1/MKK3/6/p38 and Src/TAK1/NF-kappaB-inducing kinase pathways exhibited cross-talk at the level of MKK3.
    Title: Role of Src signal transduction pathways in scatter factor-mediated cellular protection.
  2. Bcl-2 phosphorylation by activated p38 MAPK is a key event in the early induction of apoptosis under conditions of cellular stress
    Title: Bcl-2 Phosphorylation by p38 MAPK: identification of target sites and biologic consequences.
  3. The localized activation of an autocrine HGF/c-Met loop regulates Rho/ROCK activation of p38 MAPK signalling to stimulate both membrane blebbing and pseudopod formation.
    Title: Rho/ROCK-dependent pseudopodial protrusion and cellular blebbing are regulated by p38 MAPK in tumour cells exhibiting autocrine c-Met activation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase 14
Names
MAP kinase 14
MAP kinase p38 alpha
MAPK 14
mitogen-activated protein kinase p38 alpha
p38 alpha/Mxi2
p38 mitogen activated protein kinase
NP_001003206.1
XP_038538617.1
XP_038538619.1
XP_038538620.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003206.1 → NP_001003206.1  mitogen-activated protein kinase 14

    See identical proteins and their annotated locations for NP_001003206.1

    Status: PROVISIONAL

    Source sequence(s)
    AF003597
    UniProtKB/Swiss-Prot
    O02812
    UniProtKB/TrEMBL
    A0A8C0K284, A0A8I3N3D1, A0A8P0TIH5
    Related
    ENSCAFP00845011291.1, ENSCAFT00845014574.1
    Conserved Domains (1) summary
    cd07877
    Location:6 → 350
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    5493681..5569596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038682692.1 → XP_038538620.1  mitogen-activated protein kinase 14 isoform X3

    UniProtKB/TrEMBL
    A0A8C0N6Z7, A0A8I3N3K7
    Related
    ENSCAFP00845011492.1, ENSCAFT00845014830.1
    Conserved Domains (1) summary
    cl21453
    Location:6 → 257
    PKc_like; Protein Kinases, catalytic domain

  2. XM_038682689.1 → XP_038538617.1  mitogen-activated protein kinase 14 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SYM9, A0A8I3MXK0, A0A8I3N3D1, A0A8P0TIH5
    Related
    ENSCAFP00845011356.1, ENSCAFT00845014658.1
    Conserved Domains (1) summary
    cd07877
    Location:6 → 350
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)

  3. XM_038682691.1 → XP_038538619.1  mitogen-activated protein kinase 14 isoform X2

    UniProtKB/TrEMBL
    A0A8I3N8N9, A0A8P0NY88
    Related
    ENSCAFP00845011513.1, ENSCAFT00845014856.1
    Conserved Domains (1) summary
    cl21453
    Location:7 → 317
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    5148463..5221682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    5227753..5300687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    5327755..5400924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    5166000..5239239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O02812.3 GenPept UniProtKB/Swiss-Prot:O02812

Gene LinkOut

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