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REN renin [ Canis lupus familiaris (dog) ]

Gene ID: 403838, updated on 5-Mar-2024

Summary

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Official Symbol
RENprovided by VGNC
Official Full Name
reninprovided by VGNC
Primary source
VGNC:VGNC:45474
See related
Ensembl:ENSCAFG00845020764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 38
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 38 NC_051842.1 (740693..762325, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 38 NC_006620.4 (840126..850501, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 38 NC_049259.1 (1328102..1338487, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 38 NC_049298.1 (736523..746891, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 38 NC_049779.1 (1127902..1138260, complement)

Chromosome 38 - NC_051842.1Genomic Context describing neighboring genes Neighboring gene SRY-box transcription factor 13 Neighboring gene ethanolamine kinase 2 Neighboring gene uncharacterized LOC102154487 Neighboring gene KiSS-1 metastasis suppressor Neighboring gene golgi transport 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of the renin-angiotensin-aldosterone system for control of arterial blood pressure following moderate deficit in total body sodium: balance studies in freely moving dogs. Seeliger E, et al. Clin Exp Pharmacol Physiol, 2010 Feb. PMID 19930429
  2. Cloning, characterization and site-directed mutagenesis of canine renin. Bukhtiyarov Y, et al. J Biochem, 2007 Dec. PMID 17942478
  3. Normotensive sodium loading in conscious dogs: regulation of renin secretion during beta-receptor blockade. Bie P, et al. Am J Physiol Regul Integr Comp Physiol, 2009 Feb. PMID 19073902
  4. Local stress, not systemic factors, regulate gene expression of the cardiac renin-angiotensin system in vivo: a comprehensive study of all its components in the dog. Lee YA, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855304, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. With a moderate deficit in total body sodium and total body water, the renin-angiotensin-aldosterone system is the major factor controlling arterial blood pressure.
    Title: Role of the renin-angiotensin-aldosterone system for control of arterial blood pressure following moderate deficit in total body sodium: balance studies in freely moving dogs.
  2. Normotensive sodium loading in conscious dogs: regulation of renin secretion during beta1-receptor blockade.
    Title: Normotensive sodium loading in conscious dogs: regulation of renin secretion during beta-receptor blockade.
  3. Characterization of canine renin with mutations in the substrate binding site.
    Title: Cloning, characterization and site-directed mutagenesis of canine renin.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiotensin maturation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
renin
Names
angiotensinogenase
NP_001003194.1
XP_038304050.1
XP_038304051.1
XP_038304052.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003194.2 → NP_001003194.1  renin precursor

    See identical proteins and their annotated locations for NP_001003194.1

    Status: VALIDATED

    Source sequence(s)
    AY630442, JAAUVH010000370
    UniProtKB/Swiss-Prot
    Q6DYE7
    UniProtKB/TrEMBL
    A0A8C0K308, A0A8I3PE23
    Related
    ENSCAFP00845028734.1, ENSCAFT00845036704.1
    Conserved Domains (2) summary
    cd05487
    Location:77 → 402
    renin_like; Renin stimulates production of angiotensin and thus affects blood pressure
    pfam07966
    Location:30 → 65
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051842.1 Reference ROS_Cfam_1.0

    Range
    740693..762325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038448124.1 → XP_038304052.1  renin isoform X3

    UniProtKB/TrEMBL
    A0A8C0N006, A0A8P0PAT1
    Conserved Domains (1) summary
    cd05487
    Location:40 → 368
    renin_like; Renin stimulates production of angiotensin and thus affects blood pressure

  2. XM_038448122.1 → XP_038304050.1  renin isoform X1

    UniProtKB/TrEMBL
    A0A8C0N006, A0A8I3PKY8, A0A8P0PAT1
    Related
    ENSCAFP00845028677.1, ENSCAFT00845036641.1
    Conserved Domains (2) summary
    cd05487
    Location:77 → 405
    renin_like; Renin stimulates production of angiotensin and thus affects blood pressure
    pfam07966
    Location:30 → 65
    A1_Propeptide; A1 Propeptide

  3. XM_038448123.1 → XP_038304051.1  renin isoform X2

    UniProtKB/TrEMBL
    A0A8C0N006, A0A8P0PAT1
    Conserved Domains (2) summary
    pfam07966
    Location:30 → 65
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:77 → 368
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049298.1 Alternate UMICH_Zoey_3.1

    Range
    736523..746891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049779.1 Alternate UNSW_CanFamBas_1.0

    Range
    1127902..1138260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049259.1 Alternate UU_Cfam_GSD_1.0

    Range
    1328102..1338487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006620.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    840126..850501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DYE7.1 GenPept UniProtKB/Swiss-Prot:Q6DYE7

Gene LinkOut

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