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PTEN phosphatase and tensin homolog [ Canis lupus familiaris (dog) ]

Gene ID: 403832, updated on 5-Mar-2024

Summary

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Official Symbol
PTENprovided by VGNC
Official Full Name
phosphatase and tensin homologprovided by VGNC
Primary source
VGNC:VGNC:45138
See related
Ensembl:ENSCAFG00845029443
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
MMAC1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 26
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (39359420..39447205)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (37711222..37730964)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (38118261..38202372)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (37265630..37349813)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (36847668..36931645)

Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene ATPase family AAA domain containing 1 Neighboring gene uncharacterized LOC111092533 Neighboring gene uncharacterized LOC119866255 Neighboring gene uncharacterized LOC111092644

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PTEN, A Target of Microrna-374b, Contributes to the Radiosensitivity of Canine Oral Melanoma Cells. Noguchi S, et al. Int J Mol Sci, 2019 Sep 18. PMID 31540513, Free PMC Article
  2. The 5-lipoxygenase inhibitor tepoxalin induces oxidative damage and altered PTEN status prior to apoptosis in canine osteosarcoma cell lines. Loftus JP, et al. Vet Comp Oncol, 2016 Jun. PMID 24813477
  3. PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle. Feron M, et al. Am J Pathol, 2009 Apr. PMID 19264909, Free PMC Article
  4. Expression and significance of PTEN in canine mammary gland tumours. Qiu C, et al. Res Vet Sci, 2008 Oct. PMID 18082231
  5. Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma. Dickerson EB, et al. Vet Pathol, 2005 Sep. PMID 16145208

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Theexpression level of PTEN was significantly downregulated and that of miR-374b tended to be upregulated in recurrent Canine oral malignant melanoma tissues after radiation therapy compared with the pre-treatment tissues.
    Title: PTEN, A Target of Microrna-374b, Contributes to the Radiosensitivity of Canine Oral Melanoma Cells.
  2. The data suggest that overexpression of STAT3 and downregulation of PTEN may be an important step in canine prostate carcinogenesis
    Title: Is STAT3 and PTEN Expression Altered in Canine Prostate Cancer?
  3. These data suggest that inhibition of lipoxygenases and off target oxidation in osteosarcoma cells play roles in the apoptotic response.
    Title: The 5-lipoxygenase inhibitor tepoxalin induces oxidative damage and altered PTEN status prior to apoptosis in canine osteosarcoma cell lines.
  4. All the hyperplastic samples stained positive for both markers, 100% of adenomas were positive for PTEN and 86% for E-cadherin, and 69% and 34% of carcinomas were positive for PTEN and E-cadherin, respectively.
    Title: Co-localization of PTEN and E-cadherin in canine mammary hyperplasias and benign and malignant mammary tumors.
  5. increased PTEN expression and activity play a central role in PI3K/Akt/GSK3beta and p70S6K pathway modulation, which could exacerbate the consequences of dystrophin deficiency.
    Title: PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle.
  6. Low-level PETN expression might play an important role in carcinogenesis and the progression of canine mammary tumours, and PTEN protein detection might be useful in evaluating tumour development and prognosis.
    Title: Expression and significance of PTEN in canine mammary gland tumours.
  7. The relationship between the expression of the PTEN and VEGF and the clinicopathological features in canine mammary gland tumours are reported.
    Title: Expression and significance of PTEN and VEGF in canine mammary gland tumours.
  8. Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis is reported.
    Title: Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis.
  9. The presence of PTEN abnormalities that could contribute to the progression of naturally occurring canine hemangiosarcomas are reported.
    Title: Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.
  10. p21 plays a key role in mechanisms used by PTEN-deficient tumors to escape chemotherapy
    Title: Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Names
homolog of human mutated in multiple advanced cancers
inositol polyphosphate 3-phosphatase
mutated in multiple advanced cancers 1
NP_001003192.1
XP_038291997.1
XP_038291998.1
XP_038291999.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003192.1 → NP_001003192.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    See identical proteins and their annotated locations for NP_001003192.1

    Status: PROVISIONAL

    Source sequence(s)
    U92435
    UniProtKB/Swiss-Prot
    P60483
    UniProtKB/TrEMBL
    A0A8C0LQA2, A0A8C0TQA2, A0A8I3Q1J4
    Related
    ENSCAFP00845040898.1, ENSCAFT00845052143.1
    Conserved Domains (2) summary
    cd14509
    Location:24 → 181
    PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog
    pfam10409
    Location:188 → 349
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051830.1 Reference ROS_Cfam_1.0

    Range
    39359420..39447205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038436069.1 → XP_038291997.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1

    UniProtKB/TrEMBL
    A0A8C0LQA2, A0A8C0TQA2, A0A8I3Q1J4
    Related
    ENSCAFP00845040910.1, ENSCAFT00845052161.1
    Conserved Domains (2) summary
    cd14509
    Location:24 → 166
    PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog
    pfam10409
    Location:173 → 334
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  2. XM_038436071.1 → XP_038291999.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X3

    Conserved Domains (2) summary
    pfam10409
    Location:55 → 216
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:1 → 48
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. XM_038436070.1 → XP_038291998.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2

    UniProtKB/TrEMBL
    A0A8C0LQA2, A0A8C0TQA2, A0A8I3Q1J4
    Conserved Domains (2) summary
    cd14509
    Location:4 → 131
    PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog
    pfam10409
    Location:138 → 299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049286.1 Alternate UMICH_Zoey_3.1

    Range
    37265630..37349813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

    Range
    36847668..36931645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

    Range
    38118261..38202372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    37711222..37730964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60483.1 GenPept UniProtKB/Swiss-Prot:P60483

Gene LinkOut

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