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MMP14 matrix metallopeptidase 14 [ Canis lupus familiaris (dog) ]

Gene ID: 403823, updated on 5-Mar-2024

Summary

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Official Symbol
MMP14provided by VGNC
Official Full Name
matrix metallopeptidase 14provided by VGNC
Primary source
VGNC:VGNC:43277
See related
Ensembl:ENSCAFG00845002121
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
MMP-14
Orthologs
human mouse all
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Genomic context

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See MMP14 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (3291562..3301919)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (3132308..3142668)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (3306779..3317137)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (2983033..2993386)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (3044810..3055166)

Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene OXA1L mitochondrial inner membrane protein Neighboring gene solute carrier family 7 member 7 Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene U6 spliceosomal RNA Neighboring gene LDL receptor related protein 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in skeletal system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
matrix metalloproteinase-14
Names
matrix metalloproteinase 14
XP_038338654.1
XP_038400078.1
XP_038464201.1
XP_038529007.1
XP_856947.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051812.1 Reference ROS_Cfam_1.0

    Range
    3291562..3301919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038673079.1 → XP_038529007.1  matrix metalloproteinase-14

    UniProtKB/TrEMBL
    A0A8C0K4M9, A0A8C0NSG8, A0A8C0PNU1, A0A8I3MND9
    Related
    ENSCAFP00845002944.1, ENSCAFT00845003703.1
    Conserved Domains (4) summary
    cd00094
    Location:315 → 507
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:117 → 283
    Peptidase_M10; Matrixin
    pfam01471
    Location:35 → 87
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:560 → 582
    DUF3377; Domain of unknown function (DUF3377)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049268.1 Alternate UMICH_Zoey_3.1

    Range
    2983033..2993386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038482726.1 → XP_038338654.1  matrix metalloproteinase-14

    Conserved Domains (4) summary
    cd00094
    Location:315 → 507
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:117 → 283
    Peptidase_M10; Matrixin
    pfam01471
    Location:35 → 87
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:560 → 582
    DUF3377; Domain of unknown function (DUF3377)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

    Range
    3044810..3055166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038608273.1 → XP_038464201.1  matrix metalloproteinase-14

    Conserved Domains (4) summary
    cd00094
    Location:315 → 507
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:117 → 283
    Peptidase_M10; Matrixin
    pfam01471
    Location:35 → 87
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:560 → 582
    DUF3377; Domain of unknown function (DUF3377)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

    Range
    3306779..3317137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038544150.1 → XP_038400078.1  matrix metalloproteinase-14

    UniProtKB/TrEMBL
    A0A8C0K4M9, A0A8C0NSG8, A0A8C0PNU1, A0A8I3MND9
    Conserved Domains (4) summary
    cd00094
    Location:315 → 507
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:117 → 283
    Peptidase_M10; Matrixin
    pfam01471
    Location:35 → 87
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:560 → 582
    DUF3377; Domain of unknown function (DUF3377)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    3132308..3142668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_851854.6 → XP_856947.1  matrix metalloproteinase-14

    See identical proteins and their annotated locations for XP_856947.1

    UniProtKB/TrEMBL
    A0A8C0K4M9, A0A8C0NSG8, A0A8C0PNU1, A0A8I3MND9
    Conserved Domains (4) summary
    cd00094
    Location:315 → 507
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:117 → 283
    Peptidase_M10; Matrixin
    pfam01471
    Location:35 → 87
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:560 → 582
    DUF3377; Domain of unknown function (DUF3377)
Nucleotide Protein
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