TIMP1 TIMP metallopeptidase inhibitor 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: TIMP1provided by VGNC
Official Full Name: TIMP metallopeptidase inhibitor 1provided by VGNC
Primary source: VGNC:VGNC:47376
See related: Ensembl:ENSCAFG00845030572
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: TIMP-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	X	NC_051843.1 (41335929..41339499)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	X	NC_006621.4 (15576764..15580333)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	X	NC_049260.1 (41404449..41408018)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	X	NC_049299.1 (41323532..41327103)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	X	NC_049780.1 (41311800..41315371)

Chromosome X - NC_051843.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

urinary concentration lower in dogs with hip dysplasia
Title: Protein biomarkers in serum and urine for determining presence or absence of hip dysplasia in a canine model.
TIMP-1 induces an epithelial-mesenchymal transition-like phenotypic conversion in MDCK cells independent of its MMP-inhibitory domain.
Title: TIMP-1 induces an EMT-like phenotypic conversion in MDCK cells independent of its MMP-inhibitory domain.
Altered expression of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-1 contributes to atrial extracellular matrix remodeling and atrial dilatation.
Title: Matrix metalloproteinase-9/tissue inhibitors of metalloproteinase-1 expression and atrial structural remodeling in a dog model of atrial fibrillation: inhibition with angiotensin-converting enzyme.
Adipose tissue-derived mesenchymal stem cells expressed the mRNA of transforming growth factor beta (TGF-beta), IL-6, IL-8, CCL2, CCL5, VEGF,HGF, tissue inhibitor metalloproteinase-1/2, and cyclooxygenase-2 but not that of IL-10.
Title: Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells.
Knockdown of TIMP1 prevented normal cystogenesis, although the initial phase of partial epithelial to mesenchymal transition did occasionally occur
Title: Matrix metalloproteinase 13 (MMP13) and tissue inhibitor of matrix metalloproteinase 1 (TIMP1), regulated by the MAPK pathway, are both necessary for Madin-Darby canine kidney tubulogenesis.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protease binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to organic substance	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: metalloproteinase inhibitor 1

Names: tissue inhibitor of matrix metalloproteinase-1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinases 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.