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KIT KIT proto-oncogene, receptor tyrosine kinase [ Canis lupus familiaris (dog) ]

Gene ID: 403811, updated on 5-Mar-2024

Summary

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Official Symbol
KITprovided by VGNC
Official Full Name
KIT proto-oncogene, receptor tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:42422
See related
Ensembl:ENSCAFG00845011904
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
c-KIT
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
21
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 13 NC_051817.1 (47717855..47799689)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 13 NC_006595.4 (47065096..47146648)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 13 NC_049234.1 (47870472..47952050)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 13 NC_049273.1 (47394247..47475763)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 13 NC_049754.1 (46922748..47004082)

Chromosome 13 - NC_051817.1Genomic Context describing neighboring genes Neighboring gene GS homeobox 2 Neighboring gene platelet derived growth factor receptor alpha Neighboring gene uncharacterized LOC119876922 Neighboring gene uncharacterized LOC111098471

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Correlation Between KIT Expression and c-Kit Mutations in 2 Subtypes of Canine Oral Melanocytic Neoplasms. Smedley RC, et al. Vet Pathol, 2021 Jul. PMID 33910439
  2. A canine case of malignant melanoma carrying a KIT c.1725_1733del mutation treated with toceranib: a case report and in vitro analysis. Tani H, et al. BMC Vet Res, 2021 Apr 7. PMID 33827546, Free PMC Article
  3. In situ c-KIT mRNA quantification of canine cutaneous mast cell tumours and its relationship to prognostic factors. Seung BJ, et al. Vet Comp Oncol, 2021 Mar. PMID 32926564
  4. Reovirus changes the expression of anti-apoptotic and proapoptotic proteins with the c-kit downregulation in canine mast cell tumor cell lines. Hwang CC, et al. Biochem Biophys Res Commun, 2019 Sep 17. PMID 31345575
  5. A decrease in ubiquitination and resulting prolonged life-span of KIT underlies the KIT overexpression-mediated imatinib resistance of KIT mutation-driven canine mast cell tumor cells. Kobayashi M, et al. Oncol Rep, 2017 Oct. PMID 28765927

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Correlation Between KIT Expression and c-Kit Mutations in 2 Subtypes of Canine Oral Melanocytic Neoplasms.
    Title: Correlation Between KIT Expression and c-Kit Mutations in 2 Subtypes of Canine Oral Melanocytic Neoplasms.
  2. In situ c-KIT mRNA quantification of canine cutaneous mast cell tumours and its relationship to prognostic factors.
    Title: In situ c-KIT mRNA quantification of canine cutaneous mast cell tumours and its relationship to prognostic factors.
  3. A canine case of malignant melanoma carrying a KIT c.1725_1733del mutation treated with toceranib: a case report and in vitro analysis.
    Title: A canine case of malignant melanoma carrying a KIT c.1725_1733del mutation treated with toceranib: a case report and in vitro analysis.
  4. C-kit is degraded after reovirus infection in canine mast cell tumor cell lines.
    Title: Reovirus changes the expression of anti-apoptotic and proapoptotic proteins with the c-kit downregulation in canine mast cell tumor cell lines.
  5. mutations in these genes could serve as genetic markers for molecular stratification of cutaneous mast cell tumors and predictors of clinical outcome
    Title: Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours.
  6. the pan deubiquitinating enzyme inhibitor PR619 prevented imatinib induction of KIT overexpression, suggesting that the imatinib-induced decrease in KIT ubiquitination could be mediated by upregulation and/or activation of deubiquitinating enzyme(s). It may be possible that a similar mechanism of KIT overexpression underlies the acquisition of imatinib resistance in some human tumors that are driven by KIT mutation.
    Title: A decrease in ubiquitination and resulting prolonged life-span of KIT underlies the KIT overexpression-mediated imatinib resistance of KIT mutation-driven canine mast cell tumor cells.
  7. Tumors with KIT mutations showed genome-wide aberrant copy number profiles, with frequent CNAs (DNA copy number aberrations) involving genes in the p53 and RB pathways, whereas CNAs were very limited in tumors with wild-type KIT
    Title: Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade.
  8. KTN0158 inhibits KIT phosphorylation, demonstrates an acceptable safety profile in dogs, and provides objective responses in canine MCT patients with and without activating KIT mutations, supporting future clinical evaluation of KTN0158 in people.
    Title: KTN0158, a Humanized Anti-KIT Monoclonal Antibody, Demonstrates Biologic Activity against both Normal and Malignant Canine Mast Cells.
  9. the high incidence of GNSK-deletion c-kit in canine HSAs implicates KIT isoforms as possibly participating in the tumorigenesis of canine hemangiosarcomas.
    Title: Identification of the two KIT isoforms and their expression status in canine hemangiosarcomas.
  10. data indicate that c-KIT exon 11 mutations occur frequently in canine gastrointestinal stromal tumours
    Title: Analysis of c-KIT exon 11 mutations in canine gastrointestinal stromal tumours.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Fc receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Kit signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mast/stem cell growth factor receptor Kit
Names
SCFR
c-KIT gene1
proto-oncogene c-Kit
proto-oncogene tyrosine-protein kinase Kit
receptor tyrosine kinase c-kit
tyrosine-protein kinase Kit
NP_001003181.1
XP_038540451.1
XP_038540452.1
XP_038540453.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003181.1 → NP_001003181.1  mast/stem cell growth factor receptor Kit precursor

    See identical proteins and their annotated locations for NP_001003181.1

    Status: PROVISIONAL

    Source sequence(s)
    AF044249
    UniProtKB/TrEMBL
    Q9XS93
    Conserved Domains (5) summary
    cd05860
    Location:314 → 414
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:226 → 310
    IG_like; Immunoglobulin like
    cd05104
    Location:552 → 927
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:218 → 308
    ig; Immunoglobulin domain
    pfam07714
    Location:588 → 923
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051817.1 Reference ROS_Cfam_1.0

    Range
    47717855..47799689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038684523.1 → XP_038540451.1  mast/stem cell growth factor receptor Kit isoform X1

    UniProtKB/Swiss-Prot
    O97799, Q7YRV7, Q8WN23
    UniProtKB/TrEMBL
    Q9XS93
    Related
    ENSCAFP00845016654.1, ENSCAFT00845021185.1
    Conserved Domains (5) summary
    cd05104
    Location:556 → 931
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:218 → 308
    ig; Immunoglobulin domain
    pfam13927
    Location:415 → 498
    Ig_3; Immunoglobulin domain
    cd00096
    Location:270 → 280
    Ig; Ig strand E [structural motif]
    cd05860
    Location:314 → 414
    IgI_4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR); member of the I-set of IgSF domains

  2. XM_038684524.1 → XP_038540452.1  mast/stem cell growth factor receptor Kit isoform X2

    UniProtKB/TrEMBL
    Q9XS93
    Conserved Domains (5) summary
    cd05104
    Location:555 → 930
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:218 → 307
    ig; Immunoglobulin domain
    pfam13927
    Location:414 → 497
    Ig_3; Immunoglobulin domain
    cd00096
    Location:288 → 296
    Ig; Ig strand F [structural motif]
    cd05860
    Location:313 → 413
    IgI_4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR); member of the I-set of IgSF domains

  3. XM_038684525.1 → XP_038540453.1  mast/stem cell growth factor receptor Kit isoform X3

    UniProtKB/TrEMBL
    Q9XS93
    Related
    ENSCAFP00845016720.1, ENSCAFT00845021261.1
    Conserved Domains (5) summary
    cd05104
    Location:551 → 926
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:218 → 307
    ig; Immunoglobulin domain
    pfam13927
    Location:414 → 497
    Ig_3; Immunoglobulin domain
    cd00096
    Location:288 → 296
    Ig; Ig strand F [structural motif]
    cd05860
    Location:313 → 413
    IgI_4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR); member of the I-set of IgSF domains

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049273.1 Alternate UMICH_Zoey_3.1

    Range
    47394247..47475763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049754.1 Alternate UNSW_CanFamBas_1.0

    Range
    46922748..47004082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049234.1 Alternate UU_Cfam_GSD_1.0

    Range
    47870472..47952050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006595.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    47065096..47146648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O97799.2 GenPept UniProtKB/Swiss-Prot:O97799

Gene LinkOut

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