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ITGA2B integrin subunit alpha 2b [ Canis lupus familiaris (dog) ]

Gene ID: 403789, updated on 5-Mar-2024

Summary

Official Symbol
ITGA2Bprovided by VGNC
Official Full Name
integrin subunit alpha 2bprovided by VGNC
Primary source
VGNC:VGNC:42124
See related
Ensembl:ENSCAFG00845007943
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
GPIIB
Orthologs
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Genomic context

Location:
chromosome: 9
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (19744435..19758300)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (18439814..18453677)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (18925492..18939347)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (18598247..18612116)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (18781219..18795078)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097345 Neighboring gene G-patch domain containing 8 Neighboring gene family with sequence similarity 171 member A2 Neighboring gene granulin precursor

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
integrin alpha-IIb
Names
glycoprotein GPIIb
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003163.2NP_001003163.1  integrin alpha-IIb

    See identical proteins and their annotated locations for NP_001003163.1

    Status: PROVISIONAL

    Source sequence(s)
    AF170524
    UniProtKB/TrEMBL
    A0A8C0KC46, A0A8P0NG23, Q9TUN8
    Related
    ENSCAFP00845010846.1, ENSCAFT00845013996.1
    Conserved Domains (2) summary
    smart00191
    Location:384438
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:481920
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    19744435..19758300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    18598247..18612116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    18781219..18795078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    18925492..18939347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    18439814..18453677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)