ITGB3 integrin subunit beta 3 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ITGB3provided by VGNC
Official Full Name: integrin subunit beta 3provided by VGNC
Primary source: VGNC:VGNC:110811
See related: Ensembl:ENSCAFG00845021351
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: GPIIIA
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	9	NC_051813.1 (10772116..10823763, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	9	NC_006591.4 (11065645..11114120)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	9	NC_049230.1 (17635354..17683846)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	9	NC_049269.1 (9787282..9835753, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	9	NC_049750.1 (17686480..17734963)

Chromosome 9 - NC_051813.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggested that CD61 (integrin-beta3) could induce canine adipose-derived mesenchymal stem cells (cADMSCs) to differentiate into primordial germ cell (PGC)-like cells by relying on the activation of transforming growth factor beta (TGF-beta) pathway.
Title: CD61 promotes the differentiation of canine ADMSCs into PGC-like cells through modulation of TGF-β signaling.

Submit: New GeneRIF Correction

General gene information

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Markers

Itgb3 (e-PCR), detects polymorphism
- UniSTS:143631

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables fibrinogen binding	IEA Inferred from Electronic Annotation more info	PubMed
enables fibronectin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: integrin beta-3

Names: glycoprotein GPIIIa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003162.1 → NP_001003162.1 integrin beta-3 precursor

See identical proteins and their annotated locations for NP_001003162.1

Status: PROVISIONAL

Source sequence(s)

AF170525

UniProtKB/TrEMBL

O97702, Q9TUN7

Related

ENSCAFP00845029528.1, ENSCAFT00845037684.1

Conserved Domains (3) summary

pfam00362
Location:34 → 457

Integrin_beta; Integrin, beta chain

pfam07965
Location:630 → 713

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:740 → 782

Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051813.1 Reference ROS_Cfam_1.0

Range

10772116..10823763 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038674953.1 → XP_038530881.1 integrin beta-3 isoform X1

UniProtKB/TrEMBL

A0A8C0LRV9, A0A8C0REQ5, O97702

Conserved Domains (5) summary

smart00187
Location:30 → 453

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:626 → 709

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:734 → 777

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:455 → 484

I-EGF_1; Integrin beta epidermal growth factor like domain 1

NF033759
Location:461 → 636

exchanger_TraA; outer membrane exchange protein TraA
XM_038674954.1 → XP_038530882.1 integrin beta-3 isoform X2

UniProtKB/TrEMBL

O97702

Conserved Domains (3) summary

smart00187
Location:34 → 457

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:630 → 707

Integrin_B_tail; Integrin beta tail domain

pfam18372
Location:459 → 488

I-EGF_1; Integrin beta epidermal growth factor like domain 1