IL4 interleukin 4 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: IL4provided by VGNC
Official Full Name: interleukin 4provided by VGNC
Primary source: VGNC:VGNC:41987
See related: Ensembl:ENSCAFG00845010991
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: IL-4
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	11	NC_051815.1 (21758633..21767487)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	11	NC_006593.4 (19774149..19783205)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	11	NC_049232.1 (20967178..20976037)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	11	NC_049271.1 (20477129..20485985)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	11	NC_049752.1 (20324686..20333537)

Chromosome 11 - NC_051815.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The balance between IL-12/IL4 in renal tissue switches the inflammatory response arm and shows relationship with the clinical signs in Leishmania-infected dogs.
Title: The balance between IL-12/IL4 in renal tissue switches the inflammatory response arm and shows relationship with the clinical signs in Leishmania-infected dogs.
immunoreactivities of inflammatory cytokines, such as interleukin (IL)-2, its receptor (IL-2R), IL-4 and its receptor (IL-4R) in the cervical and lumbar spinal cord of young adult and aged beagle dogs, were compared.
Title: Comparison of expression of inflammatory cytokines in the spinal cord between young adult and aged beagle dogs.
In dogs with leishmaniasis, there was high expression of genes encoding IL-4 in blood leucocytes. The predominance of IL-4 gene expression in the blood of asymptomatic dogs may favour parasite replication.
Title: Cytokine gene expression in the tissues of dogs infected by Leishmania infantum.
The anti-inflammatory and anabolic effects of regulated expression of IL-4 in chondrocyte-scaffolds under in vitro inflammatory conditions, were investigated.
Title: Evidence for regulated interleukin-4 expression in chondrocyte-scaffolds under in vitro inflammatory conditions.
This study focuses on the co-expression of interleukin-4 (IL-4) and insulin-like-growth factor-1 (IGF-1), which specifically target inflammation and cartilage repair, respectively.
Title: Co-expression of insulin-like growth factor-1 and interleukin-4 in an in vitro inflammatory model.
These findings suggest that polyunsaturated fatty acids are able to influence proliferation of peripheral blood mononuclear cells in healthy and atopic dogs but do not seem to influence cytokine transcription.
Title: Effects of polyunsaturated fatty acids on isolated canine peripheral blood mononuclear cells and cytokine expression (IL-4, IFN-gamma, TGF-beta) in healthy and atopic dogs.
IL-4 expressed in canine articular chondrocytes is biologically active and suppresses inflammatory mediators in vitro.
Title: Expression of canine interleukin-4 in canine chondrocytes inhibits inflammatory cascade through STAT6.

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General gene information

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Markers

IL4 (e-PCR), detects polymorphism
- UniSTS:479899

REN71229 (e-PCR)
- UniSTS:396029

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables interleukin-4 receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell costimulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in T-helper 2 cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in activation of Janus kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response in mucosa	IEA Inferred from Electronic Annotation more info	PubMed
involved_in microglial cell activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in myeloid dendritic cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of T-helper 17 cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of acute inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of chronic inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of complement-dependent cytotoxicity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of macrophage activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of MHC class II biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of amyloid-beta clearance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of defense response to virus by host	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of eosinophil chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of interleukin-13 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of isotype switching to IgE isotypes	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of isotype switching to IgG isotypes	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of macroautophagy	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of mast cell degranulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of mononuclear cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of myoblast fusion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-4

Names: B-cell stimulatory factor 1; BSF-1; lymphocyte stimulatory factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.