NOS3 nitric oxide synthase 3 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: NOS3provided by VGNC
Official Full Name: nitric oxide synthase 3provided by VGNC
Primary source: VGNC:VGNC:43896
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: NOS
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	16	NC_051820.1 (16776276..16794533)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	16	NC_006598.4 (15662484..15680572)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	16	NC_049237.1 (15781028..15799144)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	16	NC_049276.1 (15148899..15166990)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	16	NC_049757.1 (15730292..15748445)

Chromosome 16 - NC_051820.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increases in eNOS and SOD-1 promote the coupling of oxygen delivery and efficiency in the heart during pregnancy.
Title: Role of nitric oxide in the coupling of myocardial oxygen consumption and coronary vascular dynamics during pregnancy in the dog.
NOS3 phosphorylation and enhanced cGMP/protein kinase G activity contributes to restoration of coronary vascular vasodilation during recovery from heart failure.
Title: Restoration of impaired endothelium-dependent coronary vasodilation in failing heart: role of eNOS phosphorylation and CGMP/cGK-I signaling.
The down-regulation of mitochondrial respiration by NO does not limit the kinetics of adjustment of oxidative metabolism at exercise onset.
Title: Effects of nitric oxide synthase inhibition by L-NAME on oxygen uptake kinetics in isolated canine muscle in situ.
the expression pattern of eNOS is closely associated with the development of collateral vessels, suggesting that eNOS plays an important role in arteriogenesis
Title: Expression of endothelial nitric oxide synthase in the vascular wall during arteriogenesis.

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General gene information

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Markers

Nos3 (e-PCR), detects polymorphism
- UniSTS:546896

NOS3 (e-PCR)
- UniSTS:503696

PMC155039P1 (e-PCR)
- UniSTS:271323

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables FMN binding	IEA Inferred from Electronic Annotation more info	PubMed
enables NADP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables nitric-oxide synthase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: nitric oxide synthase 3

Names: EC-NOS; NOS type III; NOSIII; cNOS; constitutive NOS; eNOS; endothelial NOS; nitric oxide synthase, endothelial

NP_001003158.2

EC 1.14.13.39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003158.2 → NP_001003158.2 nitric oxide synthase 3

Status: VALIDATED

Source sequence(s)

AAEX03010272

UniProtKB/TrEMBL

A0A8C0K110, A0A8C0PGE2, A0A8C0Q3E0

Conserved Domains (3) summary

cd00795
Location:70 → 482

NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...

pfam00258
Location:524 → 700

Flavodoxin_1; Flavodoxin

cl06868
Location:764 → 1166

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...