IL1A interleukin 1 alpha [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: IL1Aprovided by VGNC
Official Full Name: interleukin 1 alphaprovided by VGNC
Primary source: VGNC:VGNC:41956
See related: Ensembl:ENSCAFG00845011308
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	17	NC_051821.1 (37745380..37755259, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	17	NC_006599.4 (36739697..36748565, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	17	NC_049238.1 (37152126..37160990, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	17	NC_049277.1 (36881972..36890833, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	17	NC_049758.1 (36938236..36947096, complement)

Chromosome 17 - NC_051821.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in silico complete mRNA structures of the IL-1alpha and IL-1beta mRNAs in dogs.
Title: Comparison of the human and canine cytokines IL-1(alpha/beta) and TNF-alpha to orthologous other mammalians.

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General gene information

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Markers

IL1A (e-PCR), detects polymorphism
- UniSTS:505023

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables interleukin-1 receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of immature T cell proliferation in thymus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of nitric-oxide synthase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-1 alpha

Names: IL-1 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003157.2 → NP_001003157.2 interleukin-1 alpha

See identical proteins and their annotated locations for NP_001003157.2

Status: PROVISIONAL

Source sequence(s)

DQ923806

UniProtKB/Swiss-Prot

O46612, Q006K7

UniProtKB/TrEMBL

A0A8C0SHI9, A0A8I3NDD2

Related

ENSCAFP00845015762.1, ENSCAFT00845020110.1

Conserved Domains (2) summary

smart00125
Location:125 → 261

IL1; Interleukin-1 homologues

pfam02394
Location:1 → 102

IL1_propep; Interleukin-1 propeptide

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051821.1 Reference ROS_Cfam_1.0

Range

37745380..37755259 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038690436.1 → XP_038546364.1 interleukin-1 alpha isoform X1

UniProtKB/TrEMBL

A0A8C0SFW1, A0A8I3N935, A0T125

Related

ENSCAFP00845015836.1, ENSCAFT00845020202.1

Conserved Domains (2) summary

pfam02394
Location:1 → 102

IL1_propep; Interleukin-1 propeptide

cl00094
Location:98 → 203

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).