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ITGB2 integrin subunit beta 2 [ Canis lupus familiaris (dog) ]

Gene ID: 403770, updated on 5-Mar-2024

Summary

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Official Symbol
ITGB2provided by VGNC
Official Full Name
integrin subunit beta 2provided by VGNC
Primary source
VGNC:VGNC:42139
See related
Ensembl:ENSCAFG00845021592
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 31
Exon count:
20
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 31 NC_051835.1 (38125566..38152274, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 31 NC_006613.4 (37718851..37741911, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 31 NC_049252.1 (38463168..38490402, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 31 NC_049291.1 (37988075..38014617, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 31 NC_049772.1 (37949217..37972818, complement)

Chromosome 31 - NC_051835.1Genomic Context describing neighboring genes Neighboring gene PTTG1 interacting protein Neighboring gene uncharacterized LOC119867090 Neighboring gene SLX9 ribosome biogenesis factor Neighboring gene uncharacterized LOC119867092 Neighboring gene uncharacterized LOC119867095

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Canine neutrophil dysfunction caused by downregulation of beta2-integrin expression without mutation. Kobayashi S, et al. Vet Immunol Immunopathol, 2009 Aug 15. PMID 19297030
  2. Toll receptors type-2 and CR3 expression of canine monocytes and its correlation with immunohistochemistry and xenodiagnosis in visceral leishmaniasis. Amorim IF, et al. PLoS One, 2011. PMID 22140456, Free PMC Article
  3. A missense mutation in the beta-2 integrin gene (ITGB2) causes canine leukocyte adhesion deficiency. Kijas JM, et al. Genomics, 1999 Oct 1. PMID 10512685

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin beta-2
Names
B-2 integrin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051835.1 Reference ROS_Cfam_1.0

    Range
    38125566..38152274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038443684.1 → XP_038299612.1  integrin beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z0G4, A0A8I3S561, Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:35 → 450
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:625 → 703
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:728 → 770
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:462 → 479
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  2. XM_038443686.1 → XP_038299614.1  integrin beta-2 isoform X2

    UniProtKB/TrEMBL
    Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  3. XM_038443683.1 → XP_038299611.1  integrin beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z0G4, A0A8I3S561, Q9TU04
    Related
    ENSCAFP00845030038.1, ENSCAFT00845038366.1
    Conserved Domains (4) summary
    smart00187
    Location:35 → 450
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:625 → 703
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:728 → 770
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:462 → 479
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  4. XM_038443685.1 → XP_038299613.1  integrin beta-2 isoform X2

    UniProtKB/TrEMBL
    Q9TU04
    Related
    ENSCAFP00845029856.1, ENSCAFT00845038113.1
    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  5. XM_038443688.1 → XP_038299616.1  integrin beta-2 isoform X2

    UniProtKB/TrEMBL
    Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  6. XM_038443687.1 → XP_038299615.1  integrin beta-2 isoform X2

    UniProtKB/TrEMBL
    Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049291.1 Alternate UMICH_Zoey_3.1

    Range
    37988075..38014617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038518095.1 → XP_038374023.1  integrin beta-2 isoform X1

    Conserved Domains (4) summary
    smart00187
    Location:35 → 450
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:625 → 703
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:728 → 770
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:462 → 479
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  2. XM_038518097.1 → XP_038374025.1  integrin beta-2 isoform X2

    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  3. XM_038518094.1 → XP_038374022.1  integrin beta-2 isoform X1

    Conserved Domains (4) summary
    smart00187
    Location:35 → 450
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:625 → 703
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:728 → 770
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:462 → 479
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  4. XM_038518096.1 → XP_038374024.1  integrin beta-2 isoform X2

    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  5. XM_038518099.1 → XP_038374027.1  integrin beta-2 isoform X2

    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  6. XM_038518098.1 → XP_038374026.1  integrin beta-2 isoform X2

    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049772.1 Alternate UNSW_CanFamBas_1.0

    Range
    37949217..37972818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038646057.1 → XP_038501985.1  integrin beta-2 isoform X1

    Conserved Domains (4) summary
    smart00187
    Location:35 → 450
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:625 → 703
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:728 → 770
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:462 → 479
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  2. XM_038646058.1 → XP_038501986.1  integrin beta-2 isoform X2

    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  3. XM_038646059.1 → XP_038501987.1  integrin beta-2 isoform X2

    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  4. XM_038646060.1 → XP_038501988.1  integrin beta-2 isoform X2

    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049252.1 Alternate UU_Cfam_GSD_1.0

    Range
    38463168..38490402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038581651.1 → XP_038437579.1  integrin beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z0G4, A0A8I3S561, Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:35 → 450
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:625 → 703
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:728 → 770
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:462 → 479
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  2. XM_038581653.1 → XP_038437581.1  integrin beta-2 isoform X2

    UniProtKB/TrEMBL
    Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  3. XM_038581650.1 → XP_038437578.1  integrin beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0Z0G4, A0A8I3S561, Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:35 → 450
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:625 → 703
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:728 → 770
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:462 → 479
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  4. XM_038581652.1 → XP_038437580.1  integrin beta-2 isoform X2

    UniProtKB/TrEMBL
    Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  5. XM_038581654.1 → XP_038437582.1  integrin beta-2 isoform X2

    UniProtKB/TrEMBL
    Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  6. XM_038581655.1 → XP_038437583.1  integrin beta-2 isoform X2

    UniProtKB/TrEMBL
    Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006613.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    37718851..37741911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005638977.4 → XP_005639034.1  integrin beta-2 isoform X1

    See identical proteins and their annotated locations for XP_005639034.1

    UniProtKB/TrEMBL
    A0A8C0Z0G4, A0A8I3S561, Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:35 → 450
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:625 → 703
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:728 → 770
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:462 → 479
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  2. XM_014109833.3 → XP_013965308.1  integrin beta-2 isoform X2

    UniProtKB/TrEMBL
    Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  3. XM_038461843.1 → XP_038317771.1  integrin beta-2 isoform X2

    UniProtKB/TrEMBL
    Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  4. XM_038461842.1 → XP_038317770.1  integrin beta-2 isoform X2

    UniProtKB/TrEMBL
    Q9TU04
    Conserved Domains (4) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:725 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:459 → 476
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
Nucleotide Protein
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