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HTR1B 5-hydroxytryptamine receptor 1B [ Canis lupus familiaris (dog) ]

Gene ID: 403741, updated on 5-Mar-2024

Summary

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Official Symbol
HTR1Bprovided by VGNC
Official Full Name
5-hydroxytryptamine receptor 1Bprovided by VGNC
Primary source
VGNC:VGNC:110597
See related
Ensembl:ENSCAFG00845008653
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
1
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (39430205..39431374, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (38541798..38542967, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (38869413..38870583, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (38755029..38756198, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (38739892..38741061, complement)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119874277 Neighboring gene nucleolar protein of 40 kDa-like Neighboring gene U6 spliceosomal RNA Neighboring gene ATPase GET3-like Neighboring gene meiotic double-stranded break formation protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of the canine serotonin receptor 1B gene (htr1B). van den Berg L, et al. Gene, 2004 Feb 4. PMID 14729271
  2. Evidence for 5-HT1D beta but not 5-HT1D alpha receptor subtype expression in canine large coronary arteries and saphenous vein. Sgard F, et al. Cardiovasc Res, 1996 May. PMID 8763409
  3. A marker set for construction of a genetic map of the silver fox (Vulpes vulpes). Kukekova AV, et al. J Hered, 2004 May-Jun. PMID 15220384
  4. Evaluation of the serotonergic genes htr1A, htr1B, htr2A, and slc6A4 in aggressive behavior of golden retriever dogs. van den Berg L, et al. Behav Genet, 2008 Jan. PMID 18066658, Free PMC Article
  5. Sequencing of canine 5-hydroxytriptamine receptor (5-HTR) 1B, 2A, 2C genes and identification of polymorphisms in the 5-HTR1B gene. Masuda K, et al. J Vet Med Sci, 2004 Aug. PMID 15353848

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gene does not play a major role in the variation in aggression in the Golden Retrievers.
    Title: Evaluation of the serotonergic genes htr1A, htr1B, htr2A, and slc6A4 in aggressive behavior of golden retriever dogs.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in bone remodeling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of behavior IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vasoconstriction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
5-hydroxytryptamine receptor 1B
Names
5-HT-1B
5-HT1B
5-HT1D beta
5-HT1D subtype beta
5-HTR1B
5-Hydroxytryptamine 1D receptor subtype beta
serotonin receptor 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006948.1 → NP_001006949.1  5-hydroxytryptamine receptor 1B

    See identical proteins and their annotated locations for NP_001006949.1

    Status: PROVISIONAL

    Source sequence(s)
    AB193090
    UniProtKB/Swiss-Prot
    P79250, Q6VVV0
    UniProtKB/TrEMBL
    A0A8C0KGB7
    Related
    ENSCAFP00845011816.1, ENSCAFT00845015216.1
    Conserved Domains (1) summary
    cd15333
    Location:45 → 379
    7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    39430205..39431374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    38755029..38756198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    38739892..38741061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    38869413..38870583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    38541798..38542967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P79250.2 GenPept UniProtKB/Swiss-Prot:P79250

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.