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HRAS HRas proto-oncogene, GTPase [ Canis lupus familiaris (dog) ]

Gene ID: 403735, updated on 5-Mar-2024

Summary

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Official Symbol
HRASprovided by VGNC
Official Full Name
HRas proto-oncogene, GTPaseprovided by VGNC
Primary source
VGNC:VGNC:56090
See related
Ensembl:ENSCAFG00845029661
Gene type
protein coding
RefSeq status
INFERRED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
H-RAS
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (26227144..26230043, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (25291831..25293704, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (25994065..25995938, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (25736932..25738805, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (25381917..25383790, complement)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene phosphatidylserine synthase 2 Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene uncharacterized LOC111090924 Neighboring gene USP6 N-terminal-like protein Neighboring gene leucine rich repeat containing 56 Neighboring gene lamin tail domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ultra-frequent HRAS p.Q61R somatic mutation in canine acanthomatous ameloblastoma reveals pathogenic similarities with human ameloblastoma. Peralta S, et al. Vet Comp Oncol, 2019 Sep. PMID 31041834
  2. Ras protein contributes to cerebral vasospasm in a canine double-hemorrhage model. Yamaguchi M, et al. Stroke, 2004 Jul. PMID 15143294
  3. Proteomics profiling of Madin-Darby canine kidney plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition. Chen YS, et al. Mol Cell Proteomics, 2011 Feb. PMID 20511395, Free PMC Article
  4. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. Song KS, et al. J Biol Chem, 1996 Apr 19. PMID 8621645
  5. High sequence similarity within ras exons 1 and 2 in different mammalian species and phylogenetic divergence of the ras gene family. Watzinger F, et al. Mamm Genome, 1998 Mar. PMID 9501305

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonstrated that RNA sequencing, Sanger sequencing and restriction fragment length polymorphism assays to demonstrate that 94% of canine acanthomatous ameloblastoma harbor a somatic HRAS p.Q61R mutation.
    Title: Ultra-frequent HRAS p.Q61R somatic mutation in canine acanthomatous ameloblastoma reveals pathogenic similarities with human ameloblastoma.
  2. Wnt-5a is involved during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition
    Title: Proteomics profiling of Madin-Darby canine kidney plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition.
  3. Ras contributes to cerebral vasospasm, and inhibitors of Ras FTase may have potential in the management of cerebral vasospasm.
    Title: Ras protein contributes to cerebral vasospasm in a canine double-hemorrhage model.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GDP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular senescence IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
GTPase HRas
Names
ras p21
v-Ha-ras Harvey rat sarcoma viral oncogene homolog
NP_001273998.1
NP_001273999.1
XP_038279296.1
XP_038279297.1
XP_038279298.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287069.1 → NP_001273998.1  GTPase HRas isoform 1

    See identical proteins and their annotated locations for NP_001273998.1

    Status: INFERRED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAAUVH010000176
    UniProtKB/TrEMBL
    A0A8C0K1I4, A0A8C0MQL3, A0A8C0TJS5, A0A8I3Q1I3, A0A8P0NRX0
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  2. NM_001287070.1 → NP_001273999.1  GTPase HRas isoform 2

    See identical proteins and their annotated locations for NP_001273999.1

    Status: INFERRED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    JAAUVH010000176
    UniProtKB/TrEMBL
    A0A8C0K3Y8, A0A8C0MQJ2, A0A8I3Q3V9
    Related
    ENSCAFP00845041226.1, ENSCAFT00845052537.1
    Conserved Domains (1) summary
    cd04138
    Location:3 → 150
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    26227144..26230043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038423368.1 → XP_038279296.1  GTPase HRas isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1I4, A0A8C0MQL3, A0A8C0TJS5, A0A8I3Q1I3, A0A8P0NRX0
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  2. XM_038423370.1 → XP_038279298.1  GTPase HRas isoform X2

    UniProtKB/TrEMBL
    A0A8C0K3Y8, A0A8C0MQJ2, A0A8I3Q3V9
    Conserved Domains (1) summary
    cd04138
    Location:3 → 150
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  3. XM_038423369.1 → XP_038279297.1  GTPase HRas isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1I4, A0A8C0MQL3, A0A8C0TJS5, A0A8I3Q1I3, A0A8P0NRX0
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    25736932..25738805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    25381917..25383790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    25994065..25995938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    25291831..25293704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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