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DRD2 dopamine receptor D2 [ Canis lupus familiaris (dog) ]

Gene ID: 403701, updated on 5-Mar-2024

Summary

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Official Symbol
DRD2provided by VGNC
Official Full Name
dopamine receptor D2provided by VGNC
Primary source
VGNC:VGNC:40094
See related
Ensembl:ENSCAFG00845000700
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (19803212..19815852)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (19704390..19715716)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (19814856..19826385)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (19865917..19877447)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (19767231..19778550)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 5 Neighboring gene uncharacterized LOC111095829 Neighboring gene uncharacterized LOC111095830 Neighboring gene uncharacterized LOC102156066 Neighboring gene ankyrin repeat and kinase domain containing 1 Neighboring gene tetratricopeptide repeat domain 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and functional analysis of dopamine receptor subtype 2 and somatostatin receptor subtypes in canine cushing's disease. de Bruin C, et al. Endocrinology, 2008 Sep. PMID 18483151, Free PMC Article
  2. Apomorphine-induced emesis in dogs: differential sensitivity to established and novel dopamine D2/5-HT(1A) antipsychotic compounds. Depoortère R, et al. Eur J Pharmacol, 2008 Nov 12. PMID 18773888
  3. Genomic analysis and functional expression of canine dopamine D2 receptor. Myeong H, et al. Gene, 2000 Oct 17. PMID 11054572

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report differential sensitivity to established and novel dopamine D2/5-HT(1A) antipsychotic compounds in dog model of emesis.
    Title: Apomorphine-induced emesis in dogs: differential sensitivity to established and novel dopamine D2/5-HT(1A) antipsychotic compounds.
  2. Expression and functional role of D2 and somatostatin receptors in corticotroph adenoma cells.
    Title: Expression and functional analysis of dopamine receptor subtype 2 and somatostatin receptor subtypes in canine cushing's disease.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
D(2) dopamine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003110.1 → NP_001003110.1  D(2) dopamine receptor

    See identical proteins and their annotated locations for NP_001003110.1

    Status: PROVISIONAL

    Source sequence(s)
    AF293963
    UniProtKB/Swiss-Prot
    Q9GJU1
    UniProtKB/TrEMBL
    Q9GKA0
    Related
    ENSCAFP00845000880.1, ENSCAFT00845001159.1
    Conserved Domains (2) summary
    pfam00001
    Location:51 → 426
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:45 → 233
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    19803212..19815852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038664063.1 → XP_038519991.1  D(2) dopamine receptor isoform X1

    UniProtKB/TrEMBL
    A0A8C0Q1E7, Q9GK99, Q9GKA0
    Related
    ENSCAFP00845000900.1, ENSCAFT00845001179.1
    Conserved Domains (1) summary
    cd15309
    Location:35 → 408
    7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    19865917..19877447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    19767231..19778550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    19814856..19826385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    19704390..19715716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GJU1.1 GenPept UniProtKB/Swiss-Prot:Q9GJU1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Research Materials
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