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MDM2 MDM2 proto-oncogene [ Canis lupus familiaris (dog) ]

Gene ID: 403693, updated on 5-Mar-2024

Summary

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Official Symbol
MDM2provided by VGNC
Official Full Name
MDM2 proto-oncogeneprovided by VGNC
Primary source
VGNC:VGNC:43106
See related
Ensembl:ENSCAFG00845016387
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (11060051..11086867)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (10869091..10894634)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (11296600..11322142)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (10928429..10953972)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (11174449..11199967)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member E3 Neighboring gene uncharacterized LOC119873587 Neighboring gene uncharacterized LOC119873586 Neighboring gene carboxypeptidase M Neighboring gene uncharacterized LOC119873588

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Polymorphism of P53-Ets/AP1 transactivation region of MDM2 oncogene and its immunohistochemical analysis in canine tumours. Rezaie A, et al. Vet Comp Oncol, 2016 Jun. PMID 24447820
  2. Cloning, sequence analysis and expression of the cDNAs encoding the canine and equine homologues of the mouse double minute 2 (mdm2) proto-oncogene. Nasir L, et al. Cancer Lett, 2000 Apr 28. PMID 10754200
  3. A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein. Veldhoen N, et al. Oncogene, 1999 Nov 25. PMID 10597303

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tumours that exhibited mutation within the MDM2 promoter had amplification of MDM2 protein levels.
    Title: Polymorphism of P53-Ets/AP1 transactivation region of MDM2 oncogene and its immunohistochemical analysis in canine tumours.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Mdm2
Names
MDM2 alpha
Mdm2 p53 binding protein homolog
Mdm2, p53 E3 ubiquitin protein ligase homolog
RING-type E3 ubiquitin transferase Mdm2
cdm2
double minute 2 homolog
double minute 2 protein
p53-binding protein Mdm2
NP_001003103.1
XP_038534686.1
XP_038534687.1
XP_038534688.1
XP_038534689.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003103.2 → NP_001003103.1  E3 ubiquitin-protein ligase Mdm2

    See identical proteins and their annotated locations for NP_001003103.1

    Status: PROVISIONAL

    Source sequence(s)
    AF322416
    UniProtKB/Swiss-Prot
    P56950, Q95KN5
    UniProtKB/TrEMBL
    Q9GMZ6
    Conserved Domains (3) summary
    pfam00641
    Location:299 → 328
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:45 → 92
    SWIB; SWIB/MDM2 domain
    pfam13920
    Location:432 → 479
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    11060051..11086867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038678758.1 → XP_038534686.1  E3 ubiquitin-protein ligase Mdm2 isoform X1

    UniProtKB/Swiss-Prot
    P56950, Q95KN5
    UniProtKB/TrEMBL
    Q9GMZ6
    Related
    ENSCAFP00845023383.1, ENSCAFT00845029772.1
    Conserved Domains (3) summary
    cd16783
    Location:431 → 487
    mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
    cd17672
    Location:25 → 107
    MDM2; p53-binding domain found in E3 ubiquitin-protein ligase MDM2 and similar proteins
    pfam00641
    Location:299 → 328
    zf-RanBP; Zn-finger in Ran binding protein and others

  2. XM_038678759.1 → XP_038534687.1  E3 ubiquitin-protein ligase Mdm2 isoform X1

    UniProtKB/Swiss-Prot
    P56950, Q95KN5
    UniProtKB/TrEMBL
    Q9GMZ6
    Conserved Domains (3) summary
    cd16783
    Location:431 → 487
    mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
    cd17672
    Location:25 → 107
    MDM2; p53-binding domain found in E3 ubiquitin-protein ligase MDM2 and similar proteins
    pfam00641
    Location:299 → 328
    zf-RanBP; Zn-finger in Ran binding protein and others

  3. XM_038678761.1 → XP_038534689.1  E3 ubiquitin-protein ligase Mdm2 isoform X3

    UniProtKB/TrEMBL
    Q9GK41
    Related
    ENSCAFP00845023282.1, ENSCAFT00845029644.1
    Conserved Domains (3) summary
    cd16783
    Location:370 → 426
    mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
    pfam00641
    Location:238 → 267
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl38907
    Location:1 → 46
    SWIB-MDM2; SWIB/MDM2 domain family

  4. XM_038678760.1 → XP_038534688.1  E3 ubiquitin-protein ligase Mdm2 isoform X2

    UniProtKB/TrEMBL
    Q9GK41
    Conserved Domains (3) summary
    cd16783
    Location:382 → 438
    mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
    pfam00641
    Location:250 → 279
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl38907
    Location:1 → 58
    SWIB-MDM2; SWIB/MDM2 domain family

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    10928429..10953972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    11174449..11199967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    11296600..11322142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    10869091..10894634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56950.1 GenPept UniProtKB/Swiss-Prot:P56950

Gene LinkOut

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