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SLC2A4 solute carrier family 2 member 4 [ Canis lupus familiaris (dog) ]

Gene ID: 403673, updated on 5-Mar-2024

Summary

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Official Symbol
SLC2A4provided by VGNC
Official Full Name
solute carrier family 2 member 4provided by VGNC
Primary source
VGNC:VGNC:53442
See related
Ensembl:ENSCAFG00845020724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
GLUT4
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (32343488..32349420)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (32376140..32382065)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (32444733..32450658)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (32308943..32314868)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (32267746..32273663)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene claudin 7 Neighboring gene Y-box binding protein 2 Neighboring gene uncharacterized LOC111095872

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conditioning causes an increase in glucose transporter-4 levels in mononuclear cells in sled dogs. Schnurr TM, et al. Int J Biochem Cell Biol, 2014 Oct. PMID 25236492, Free PMC Article
  2. Intervention of rosiglitazone on myocardium Glut-4 mRNA expression during ischemia-reperfusion injury in cardio-pulmonary bypass in dogs. Liu B, et al. Mol Cell Biochem, 2013 Jan. PMID 23111893
  3. Cardiac glucose uptake and suppressed expression/translocation of myocardium glucose transport-4 in dogs undergoing ischemia-reperfusion. Liang GY, et al. Exp Biol Med (Maywood), 2008 Sep. PMID 18535164
  4. Chronic heart failure selectively induces regional heterogeneity of insulin-responsive glucose transporters. Ware B, et al. Am J Physiol Regul Integr Comp Physiol, 2011 Nov. PMID 21849635, Free PMC Article
  5. A method for the large-scale cloning of nuclear proteins and nuclear targeting sequences on a functional basis. Pichon B, et al. Anal Biochem, 2000 Sep 10. PMID 10964405

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that the state of conditioning had a significant effect on the glucose transporter-4 protein (GLUT4) expression at the surface of mononuclear cells.
    Title: Conditioning causes an increase in glucose transporter-4 levels in mononuclear cells in sled dogs.
  2. Damage of cardiac function during cardiopulomnary bypass are mostly associated with lower expression of Glut-4 mRNA.
    Title: Intervention of rosiglitazone on myocardium Glut-4 mRNA expression during ischemia-reperfusion injury in cardio-pulmonary bypass in dogs.
  3. Chronic heart failure selectively induces regional heterogeneity of insulin-responsive glucose transporters, GLUT4/12.
    Title: Chronic heart failure selectively induces regional heterogeneity of insulin-responsive glucose transporters.
  4. Suppressed translocation of GLUT-4 was also evident in dogs receiving 30-min ischemia
    Title: Cardiac glucose uptake and suppressed expression/translocation of myocardium glucose transport-4 in dogs undergoing ischemia-reperfusion.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glucose transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 4
Names
GLUT-4
Insulin-responsive glucose transporter
glucose transporter type 4, insulin-responsive

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159327.2 → NP_001152799.1  solute carrier family 2, facilitated glucose transporter member 4

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000371
    UniProtKB/TrEMBL
    A0A8C0K899, A0A8C0Q762, A0A8I3PA13
    Related
    ENSCAFP00845028720.1, ENSCAFT00845036689.1
    Conserved Domains (1) summary
    pfam00083
    Location:27 → 483
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    32343488..32349420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038664061.1 → XP_038519989.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0K899
    Conserved Domains (1) summary
    cd17431
    Location:51 → 499
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

  2. XM_038664062.1 → XP_038519990.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KB74, A0A8C0QYG1
    Conserved Domains (1) summary
    cl28910
    Location:1 → 317
    MFS; Major Facilitator Superfamily

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    32308943..32314868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    32267746..32273663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    32444733..32450658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    32376140..32382065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XST2.1 GenPept UniProtKB/Swiss-Prot:Q9XST2

Gene LinkOut

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