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ESR2 estrogen receptor 2 [ Canis lupus familiaris (dog) ]

Gene ID: 403639, updated on 5-Mar-2024

Summary

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Official Symbol
ESR2provided by VGNC
Official Full Name
estrogen receptor 2provided by VGNC
Primary source
VGNC:VGNC:40477
See related
Ensembl:ENSCAFG00845001856
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
ERBETA
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (38869013..38937387, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (38338303..38407225, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (38921461..38990144, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (38489186..38557866, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (38561325..38629870, complement)

Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing nuclear envelope protein 2 Neighboring gene 40S ribosomal protein S29-like Neighboring gene 28S ribosomal protein S36, mitochondrial-like Neighboring gene WW domain-binding protein 11-like Neighboring gene DNA mismatch repair protein Msh6-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of estrogen receptor alpha and beta genes in the mediobasal hypothalamus, pituitary and ovary during the canine estrous cycle. Hatoya S, et al. Neurosci Lett, 2003 Aug 21. PMID 12873744
  2. A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells. Torres CG, et al. Oncol Rep, 2009 Jun. PMID 19424616
  3. Sex steroid receptors and apoptosis-related proteins are differentially expressed in polycystic ovaries of adult dogs. Chuffa LG, et al. Tissue Cell, 2016 Feb. PMID 26767421
  4. Immunolocalization of androgen receptors, estrogen alpha receptors, and estrogen beta receptors in experimentally induced canine prostatic hyperplasia. Gallardo F, et al. J Androl, 2009 May-Jun. PMID 19136389

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We concluded that sex steroid receptors and apoptotic proteins are differentially expressed in the follicles of adult dogs with polystic ovaries
    Title: Sex steroid receptors and apoptosis-related proteins are differentially expressed in polycystic ovaries of adult dogs.
  2. AR, ER alpha, and ER beta are differently expressed in canine prostate tissue
    Title: Immunolocalization of androgen receptors, estrogen alpha receptors, and estrogen beta receptors in experimentally induced canine prostatic hyperplasia.
  3. A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells.
    Title: A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear estrogen receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
estrogen receptor beta

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051812.1 Reference ROS_Cfam_1.0

    Range
    38869013..38937387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038673834.1 → XP_038529762.1  estrogen receptor beta

    UniProtKB/TrEMBL
    A0A8C0K1X2, A0A8P0NH92
    Related
    ENSCAFP00845002631.1, ENSCAFT00845003321.1
    Conserved Domains (3) summary
    cd06949
    Location:282 → 517
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:163 → 244
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:31 → 144
    ERbeta_N; Estrogen receptor beta

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049268.1 Alternate UMICH_Zoey_3.1

    Range
    38489186..38557866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038483454.1 → XP_038339382.1  estrogen receptor beta

    Conserved Domains (3) summary
    cd06949
    Location:282 → 517
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:163 → 244
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:31 → 144
    ERbeta_N; Estrogen receptor beta

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

    Range
    38561325..38629870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038609030.1 → XP_038464958.1  estrogen receptor beta

    Conserved Domains (3) summary
    cd06949
    Location:282 → 517
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:163 → 244
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:31 → 144
    ERbeta_N; Estrogen receptor beta

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

    Range
    38921461..38990144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038544913.1 → XP_038400841.1  estrogen receptor beta

    UniProtKB/TrEMBL
    A0A8C0K1X2, A0A8C0QK22, A0A8P0NH92
    Conserved Domains (3) summary
    cd06949
    Location:282 → 517
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:163 → 244
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:31 → 144
    ERbeta_N; Estrogen receptor beta

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    38338303..38407225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038589140.1 → XP_038445068.1  estrogen receptor beta

    UniProtKB/TrEMBL
    A0A8C0K1X2, A0A8C0QK22, A0A8P0NH92
    Conserved Domains (3) summary
    cd06949
    Location:282 → 517
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:163 → 244
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:31 → 144
    ERbeta_N; Estrogen receptor beta
Nucleotide Protein
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