U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TIMP2 TIMP metallopeptidase inhibitor 2 [ Canis lupus familiaris (dog) ]

Gene ID: 403633, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
TIMP2
Gene description
TIMP metallopeptidase inhibitor 2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TIMP2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (3140666..3188540)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (3146850..3191997) , (3159531..3168419)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (3369678..3414817)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (3162992..3208134) , (3175669..3184556)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (3288768..3333886) , (3301440..3310326)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102153844 Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene ubiquitin specific peptidase 36 Neighboring gene cytohesin 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cryoplasty for Canine Iliac Artery Stenosis and its Impact on Expression of TIMP-2 and MMP-2. Wu Z, et al. Vasc Endovascular Surg, 2015 Jul-Aug. PMID 26335992
  2. The cloning and expression of matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase 2 in normal canine lymph nodes and in canine lymphoma. Newman RG, et al. Res Vet Sci, 2008 Apr. PMID 17604063
  3. Dynamic alterations of connexin43, matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 during ventricular fibrillation in canine. Wang J, et al. Mol Cell Biochem, 2014 Jun. PMID 24639125
  4. Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases and vascular endothelial growth factor in canine mast cell tumours. Giantin M, et al. J Comp Pathol, 2012 Nov. PMID 22520817
  5. Cloning of canine IL-1ra, TNFR and TIMP-2. Campbell SE, et al. Vet Immunol Immunopathol, 2001 Jan 26. PMID 11182158

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suggest cryoplasty increases the expression of TIMP-2 and decreases the expression of MMP-2, thereby inhibiting vascular hyperplasia and collagen fibers synthesis in the stenotic vessels.
    Title: Cryoplasty for Canine Iliac Artery Stenosis and its Impact on Expression of TIMP-2 and MMP-2.
  2. the alteration of Cx43 and/or phosphorylated Cx43 levels and the imbalance of MMP-2 and TIMP-2 may contribute to the initiation and/or persistence of ventricular fibrillation.
    Title: Dynamic alterations of connexin43, matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 during ventricular fibrillation in canine.
  3. This study demonstrates that MMP-9, TIMP-2 and VEGF-A expression is related to histological grade in canine mast cell tumors.
    Title: Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases and vascular endothelial growth factor in canine mast cell tumours.
  4. Adipose tissue-derived mesenchymal stem cells expressed the mRNA of transforming growth factor beta (TGF-beta), IL-6, IL-8, CCL2, CCL5, VEGF,HGF, tissue inhibitor metalloproteinase-1/2, and cyclooxygenase-2 but not that of IL-10.
    Title: Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells.
  5. The cloning of matrix metallopeptidase 2 (MMP2)and its expression with tissue inhibitor of matrix metalloproteinase 2 (TIMP2) in canine lymph nodes and lymphomas are reported.
    Title: The cloning and expression of matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase 2 in normal canine lymph nodes and in canine lymphoma.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to organic substance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
metalloproteinase inhibitor 2; LOW QUALITY PROTEIN: metalloproteinase inhibitor 2
Names
TIMP-2
tissue inhibitor of matrix metalloproteinase-2
tissue inhibitor of metalloproteinase-2
tissue inhibitor of metalloproteinases 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003082.1 → NP_001003082.1  metalloproteinase inhibitor 2 precursor

    See identical proteins and their annotated locations for NP_001003082.1

    Status: PROVISIONAL

    Source sequence(s)
    AF112115
    UniProtKB/Swiss-Prot
    O77804, Q9TTE9, Q9TTY1
    UniProtKB/TrEMBL
    A0A8C0K5I4
    Conserved Domains (1) summary
    cd03585
    Location:27 → 209
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    3140666..3188540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038674948.1 → XP_038530876.1  metalloproteinase inhibitor 2 isoform X3

    Conserved Domains (1) summary
    cd03585
    Location:14 → 179
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

  2. XM_038674947.1 → XP_038530875.1  metalloproteinase inhibitor 2 isoform X2

    Conserved Domains (1) summary
    cd03585
    Location:48 → 214
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

  3. XM_038674949.1 → XP_038530877.1  metalloproteinase inhibitor 2 isoform X4

    Conserved Domains (1) summary
    cd03585
    Location:2 → 166
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

  4. XM_038674945.1 → XP_038530873.1  metalloproteinase inhibitor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RBM2

  5. XM_038674944.1 → XP_038530872.1  metalloproteinase inhibitor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RBM2

  6. XM_038674946.1 → XP_038530874.1  metalloproteinase inhibitor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RBM2

  7. XM_038674950.1 → XP_038530878.1  metalloproteinase inhibitor 2 isoform X5

    Conserved Domains (1) summary
    cd03585
    Location:2 → 166
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

  8. XM_038674951.1 → XP_038530879.1  metalloproteinase inhibitor 2 isoform X5

    Conserved Domains (1) summary
    cd03585
    Location:2 → 166
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    3162992..3208134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

  2. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    3175669..3184556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    3288768..3333886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

  2. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    3301440..3310326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    3369678..3414817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    3146850..3191997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

  2. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    3159531..3168419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TTY1.2 GenPept UniProtKB/Swiss-Prot:Q9TTY1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.