ADIPOQ adiponectin, C1Q and collagen domain containing [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ADIPOQprovided by VGNC
Official Full Name: adiponectin, C1Q and collagen domain containingprovided by VGNC
Primary source: VGNC:VGNC:37656
See related: Ensembl:ENSCAFG00845021949
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: ACDC; APM1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	34	NC_051838.1 (19309590..19321861)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	34	NC_006616.4 (23492088..23493907)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	34	NC_049255.1 (19582218..19584037)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	34	NC_049294.1 (19349075..19350894)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	34	NC_049775.1 (19348981..19350799)

Chromosome 34 - NC_051838.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serum concentrations of adiponectin were significantly negatively associated with concentrations of total thyroxine (P <0.05) and positively correlated with concentrations of cholesterol (r = 0.6, P <0.01) in hypothyroid dogs.
Title: Increased serum concentrations of adiponectin in canine hypothyroidism.
This study evaluated the differences in leptin, adiponectin, and serotonin between lean and obese dogs.
Title: Leptin, adiponectin and serotonin levels in lean and obese dogs.
The etiology of blindness in dogs with pituitary dependent hypercortisolism, including the role of adiponectin, interleukin 6, insulin, and nitric oxide, is reported.
Title: Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism.
no direct association was observed between adiponectin concentration and either insulin sensitivity or beta-cell function
Title: Compensation for obesity-induced insulin resistance in dogs: assessment of the effects of leptin, adiponectin, and glucagon-like peptide-1 using path analysis.
obesity might decrease adiponectin concentrations in intact but not in neutered dogs
Title: Adiposity and adiponectin in dogs: investigation of causes of discrepant results between two studies.
These results suggest that adiponectin is an index of adiposity and a target molecule for studies on diseases associated with obesity in dogs.
Title: Canine adiponectin: cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesity.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: adiponectin

Names: adipocyte, C1Q and collagen domain containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006644.1 → NP_001006645.1 adiponectin precursor

See identical proteins and their annotated locations for NP_001006645.1

Status: PROVISIONAL

Source sequence(s)

AB110099

UniProtKB/TrEMBL

B5U1S6, Q76C76

Conserved Domains (2) summary

smart00110
Location:106 → 242

C1Q; Complement component C1q domain

pfam01391
Location:42 → 104

Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051838.1 Reference ROS_Cfam_1.0

Range

19309590..19321861

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038445379.1 → XP_038301307.1 adiponectin isoform X2

UniProtKB/TrEMBL

A0A8C0QWB7, A0A8I3PEP4, A0A8P0PEQ7, B5U1S6

Conserved Domains (2) summary

smart00110
Location:106 → 242

C1Q; Complement component C1q domain

pfam01391
Location:45 → 104

Collagen; Collagen triple helix repeat (20 copies)
XM_038445378.1 → XP_038301306.1 adiponectin isoform X1

UniProtKB/TrEMBL

A0A0B4J198, A0A3B0IPB0, A0A8C0SXA1, B5U1S6

Related

ENSCAFP00845030338.1, ENSCAFT00845038743.1

Conserved Domains (2) summary

smart00110
Location:115 → 251

C1Q; Complement component C1q domain

pfam01391
Location:54 → 113

Collagen; Collagen triple helix repeat (20 copies)
XM_038445380.1 → XP_038301308.1 adiponectin isoform X2

UniProtKB/TrEMBL

A0A8C0QWB7, A0A8I3PEP4, A0A8P0PEQ7, B5U1S6

Related

ENSCAFP00845030363.1, ENSCAFT00845038776.1

Conserved Domains (2) summary

smart00110
Location:106 → 242

C1Q; Complement component C1q domain

pfam01391
Location:45 → 104

Collagen; Collagen triple helix repeat (20 copies)
XM_038445381.1 → XP_038301309.1 adiponectin isoform X2

UniProtKB/TrEMBL

A0A8C0QWB7, A0A8I3PEP4, A0A8P0PEQ7, B5U1S6

Conserved Domains (2) summary

smart00110
Location:106 → 242

C1Q; Complement component C1q domain

pfam01391
Location:45 → 104

Collagen; Collagen triple helix repeat (20 copies)