U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PGR progesterone receptor [ Canis lupus familiaris (dog) ]

Gene ID: 403621, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
PGRprovided by VGNC
Official Full Name
progesterone receptorprovided by VGNC
Primary source
VGNC:VGNC:44469
See related
Ensembl:ENSCAFG00845015739
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
PR
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 21
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (609104..717242)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (461376..566187)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (532736..637643)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (392996..497928)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (478480..583792)

Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene HIG1 domain family member 1A, mitochondrial-like Neighboring gene 60S ribosomal protein L7-like Neighboring gene Rho GTPase activating protein 42 Neighboring gene uncharacterized LOC111091473

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Marginal activity of progesterone receptor B (PR-B) in dogs but high incidence of mammary cancer. Gracanin A, et al. J Steroid Biochem Mol Biol, 2014 Oct. PMID 25158022
  2. Oestrogen and progesterone receptor gene expression in canine oocytes and cumulus cells throughout the oestrous cycle. Gonçalves JS, et al. Reprod Domest Anim, 2009 Jul. PMID 19754577
  3. Uterine progesterone receptor and leukaemia inhibitory factor mRNA expression in canine pregnancy. Schäfer-Somi S, et al. Reprod Domest Anim, 2009 Jul. PMID 19754547
  4. Comparison of steroid receptor expression in normal, dysplastic, and neoplastic canine and feline mammary tissues. Millanta F, et al. Res Vet Sci, 2005 Dec. PMID 16054892
  5. Cloning and cellular localization of the canine progesterone receptor: co-localization with growth hormone in the mammary gland. Lantinga-van Leeuwen IS, et al. J Steroid Biochem Mol Biol, 2000 Dec 31. PMID 11282275

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Marginal activity of progesterone receptor B in dogs but high incidence of mammary cancer
    Title: Marginal activity of progesterone receptor B (PR-B) in dogs but high incidence of mammary cancer.
  2. ER, PgR and E-cadherin are expressed in canine mammary gland columnar cell lesions; cytokeratin 34betaE-12, HER-2 and P53 are not expressed
    Title: Columnar cell lesions of the canine mammary gland: pathological features and immunophenotypic analysis.
  3. It was found that canine oocytes express estrogen receptor alpha and estrogen receptor beta throughout the oestrous cycle, however, there is a lack of progesterone receptor expression in all these phases.
    Title: Oestrogen and progesterone receptor gene expression in canine oocytes and cumulus cells throughout the oestrous cycle.
  4. The roles of leukemia inhibitory factor and progesterone receptor expression on the establishment and maintenance of canine pregnancy are reported.
    Title: Uterine progesterone receptor and leukaemia inhibitory factor mRNA expression in canine pregnancy.
  5. In bitches no significant variation in PR expression was observed between normal tissue, dysplasias, and benign neoplasms, but was significantly lower in mammary carcinomas
    Title: Comparison of steroid receptor expression in normal, dysplastic, and neoplastic canine and feline mammary tissues.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
progesterone receptor
Names
nuclear receptor subfamily 3 group C member 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003074.1 → NP_001003074.1  progesterone receptor

    See identical proteins and their annotated locations for NP_001003074.1

    Status: PROVISIONAL

    Source sequence(s)
    AF177470
    UniProtKB/Swiss-Prot
    Q9GLW0
    UniProtKB/TrEMBL
    A0A8C0KED9, A0A8I3P6B0
    Related
    ENSCAFP00845022110.1, ENSCAFT00845028099.1
    Conserved Domains (3) summary
    cd07074
    Location:692 → 939
    NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
    cd07172
    Location:569 → 646
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02161
    Location:1 → 570
    Prog_receptor; Progesterone receptor

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051825.1 Reference ROS_Cfam_1.0

    Range
    609104..717242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038429442.1 → XP_038285370.1  progesterone receptor isoform X1

    Conserved Domains (3) summary
    cd07172
    Location:395 → 471
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02161
    Location:1 → 396
    Prog_receptor; Progesterone receptor
    cl11397
    Location:466 → 663
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  2. XM_038429443.1 → XP_038285371.1  progesterone receptor isoform X2

    Conserved Domains (3) summary
    cd07074
    Location:166 → 413
    NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
    cd07172
    Location:43 → 120
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02161
    Location:26 → 44
    Prog_receptor; Progesterone receptor

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049281.1 Alternate UMICH_Zoey_3.1

    Range
    392996..497928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

    Range
    478480..583792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

    Range
    532736..637643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    461376..566187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GLW0.1 GenPept UniProtKB/Swiss-Prot:Q9GLW0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.