PPP2CA protein phosphatase 2 catalytic subunit alpha [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PPP2CAprovided by VGNC
Official Full Name: protein phosphatase 2 catalytic subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:111654
See related: Ensembl:ENSCAFG00845012605
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	11	NC_051815.1 (23189481..23211243, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	11	NC_006593.4 (21134537..21156029, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	11	NC_049232.1 (22397162..22418841, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	11	NC_049271.1 (21889485..21911229, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	11	NC_049752.1 (21754643..21776444, complement)

Chromosome 11 - NC_051815.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

QLalpha12-stimulated activation of JNK was blocked by inhibiting PP2A
Title: Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha.

Submit: New GeneRIF Correction

General gene information

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Markers

Ppp2ca (e-PCR), detects polymorphism
- UniSTS:526870

Ppp2ca (e-PCR), detects polymorphism
- UniSTS:526871

PMC22838P1 (e-PCR)
- UniSTS:272153

D5S2786 (e-PCR)
- UniSTS:473854

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in peptidyl-serine dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Names: type 2A protein phosphatase catalytic subunit

NP_001003063.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003063.1 → NP_001003063.1 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

See identical proteins and their annotated locations for NP_001003063.1

Status: PROVISIONAL

Source sequence(s)

AF448499

UniProtKB/TrEMBL

A0A8I3NN81, A0A8P0NV14, Q8WN16

Related

ENSCAFP00845017653.1, ENSCAFT00845022478.1

Conserved Domains (2) summary

PTZ00239
Location:8 → 309

PTZ00239; serine/threonine protein phosphatase 2A; Provisional

cd07415
Location:9 → 293

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain