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PPARG peroxisome proliferator activated receptor gamma [ Canis lupus familiaris (dog) ]

Gene ID: 403606, updated on 5-Mar-2024

Summary

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Official Symbol
PPARGprovided by VGNC
Official Full Name
peroxisome proliferator activated receptor gammaprovided by VGNC
Primary source
VGNC:VGNC:44836
See related
Ensembl:ENSCAFG00845029007
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
PPAR-GAMMA
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (6163453..6294865, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (6170697..6244070, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (6208181..6281750, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (5878834..5952191, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (6232700..6306060, complement)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene replication protein A 32 kDa subunit-like Neighboring gene MKRN2 opposite strand Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene uncharacterized LOC111091237 Neighboring gene uncharacterized LOC119864630 Neighboring gene nucleobindin-1-like Neighboring gene uncharacterized LOC102156438

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Peroxisome proliferator-activated receptor γ modulates renal crystal retention associated with high oxalate concentration by regulating tubular epithelial cellular transdifferentiation. Li S, et al. J Cell Physiol, 2019 Mar. PMID 30317563
  2. Expression and functional implications of peroxisome proliferator-activated receptor gamma (PPARγ) in canine reproductive tissues during normal pregnancy and parturition and at antiprogestin induced abortion. Kowalewski MP, et al. Theriogenology, 2011 Mar 15. PMID 21196045
  3. Cloning, expression and investigation for polymorphisms of canine peroxisome proliferator-activated receptors. Nishii N, et al. Comp Biochem Physiol B Biochem Mol Biol, 2007 Aug. PMID 17512769
  4. Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. Kabir M, et al. Am J Physiol Endocrinol Metab, 2005 Feb. PMID 15522994

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cytosolic phospholipase A2 regulates lipid homeostasis under osmotic stress through PPARgamma.
    Title: Cytosolic phospholipase A(2) regulates lipid homeostasis under osmotic stress through PPARγ.
  2. our results revealed that endogenic PPARgamma activity plays a vital regulatory role in crystal clearance, subsequent crystal adherence, and CaOx stone formation via manipulating the transdifferentiation of renal tubular epithelial cells.
    Title: Peroxisome proliferator-activated receptor γ modulates renal crystal retention associated with high oxalate concentration by regulating tubular epithelial cellular transdifferentiation.
  3. a regulatory role of peroxisome proliferator-activated receptor gamma (PPARgamma) in canine placental development possibly through influencing the invasion of fetal trophoblast cells is suggested
    Title: Expression and functional implications of peroxisome proliferator-activated receptor gamma (PPARγ) in canine reproductive tissues during normal pregnancy and parturition and at antiprogestin induced abortion.
  4. Investigations for polymorphisms of PPARgamma revealed a silent polymorphism, C1362T, in 3 of 92 dogs.
    Title: Cloning, expression and investigation for polymorphisms of canine peroxisome proliferator-activated receptors.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
peroxisome proliferator-activated receptor gamma
Names
nuclear receptor subfamily 1 group C member 3
peroxisome proliferative activated receptor, gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024632.2 → NP_001019803.1  peroxisome proliferator-activated receptor gamma

    See identical proteins and their annotated locations for NP_001019803.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ016141
    UniProtKB/Swiss-Prot
    Q4U3Q4
    Related
    ENSCAFP00845040272.1, ENSCAFT00845051338.1
    Conserved Domains (3) summary
    cd06932
    Location:237 → 504
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:138 → 221
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:31 → 108
    PPARgamma_N; PPAR gamma N-terminal region

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    6163453..6294865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038426356.1 → XP_038282284.1  peroxisome proliferator-activated receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0K254
    Conserved Domains (3) summary
    cd06932
    Location:207 → 474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:1 → 78
    PPARgamma_N; PPAR gamma N-terminal region

  2. XM_038426360.1 → XP_038282288.1  peroxisome proliferator-activated receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0K254
    Conserved Domains (3) summary
    cd06932
    Location:207 → 474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:1 → 78
    PPARgamma_N; PPAR gamma N-terminal region

  3. XM_038426357.1 → XP_038282285.1  peroxisome proliferator-activated receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0K254
    Conserved Domains (3) summary
    cd06932
    Location:207 → 474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:1 → 78
    PPARgamma_N; PPAR gamma N-terminal region

  4. XM_038426358.1 → XP_038282286.1  peroxisome proliferator-activated receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0K254
    Conserved Domains (3) summary
    cd06932
    Location:207 → 474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:1 → 78
    PPARgamma_N; PPAR gamma N-terminal region

  5. XM_038426355.1 → XP_038282283.1  peroxisome proliferator-activated receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0K254
    Conserved Domains (3) summary
    cd06932
    Location:207 → 474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:1 → 78
    PPARgamma_N; PPAR gamma N-terminal region

  6. XM_038426359.1 → XP_038282287.1  peroxisome proliferator-activated receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0K254
    Conserved Domains (3) summary
    cd06932
    Location:207 → 474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:1 → 78
    PPARgamma_N; PPAR gamma N-terminal region

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    5878834..5952191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    6232700..6306060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    6208181..6281750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    6170697..6244070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4U3Q4.1 GenPept UniProtKB/Swiss-Prot:Q4U3Q4

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