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THRA thyroid hormone receptor alpha [ Canis lupus familiaris (dog) ]

Gene ID: 403601, updated on 5-Mar-2024

Summary

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Official Symbol
THRAprovided by VGNC
Official Full Name
thyroid hormone receptor alphaprovided by VGNC
Primary source
VGNC:VGNC:55828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (23262655..23286090, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (21941798..21965472, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (22419817..22443287, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (22036085..22059532, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (22295080..22318722, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene MSL complex subunit 1 Neighboring gene nuclear receptor subfamily 1 group D member 1 Neighboring gene uncharacterized LOC119881585 Neighboring gene mediator complex subunit 24 Neighboring gene small nucleolar RNA SNORD124 Neighboring gene colony stimulating factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Upregulation of thyroid hormone receptor beta 1 and beta 2 messenger RNA in the myocardium of dogs with dilated cardiomyopathy or chronic valvular disease. Shahrara S, et al. Am J Vet Res, 1999 Jul. PMID 10407478

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in thyroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
thyroid hormone receptor alpha
Names
thyroid hormone receptor alpha2
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286862.2 → NP_001273791.1  thyroid hormone receptor alpha

    See identical proteins and their annotated locations for NP_001273791.1

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000313
    UniProtKB/TrEMBL
    A0A8C0PT61, A0A8P0T7I2
    Conserved Domains (2) summary
    cd06935
    Location:162 → 404
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:52 → 138
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    23262655..23286090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    22036085..22059532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    22295080..22318722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    22419817..22443287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21941798..21965472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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