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AR androgen receptor [ Canis lupus familiaris (dog) ]

Gene ID: 403588, updated on 3-Apr-2024

Summary

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Official Symbol
ARprovided by VGNC
Official Full Name
androgen receptorprovided by VGNC
Primary source
VGNC:VGNC:38023
See related
Ensembl:ENSCAFG00845028051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (52938974..53121719)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (42802440..42991502)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (52163183..52345868)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (50910919..51093566)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (52242285..52424949)

Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene RNA-binding protein EWS-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene 60 kDa heat shock protein, mitochondrial-like Neighboring gene U6 spliceosomal RNA Neighboring gene RNA-binding protein EWS-like Neighboring gene oligophrenin 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comprehensive Genomic Profiling of Androgen-Receptor-Negative Canine Prostate Cancer. Laufer-Amorim R, et al. Int J Mol Sci, 2019 Mar 28. PMID 30925701, Free PMC Article
  2. Variability of CAG tandem repeats in exon 1 of the androgen receptor gene is not related with dog intersexuality. Nowacka-Woszuk J, et al. Anim Reprod Sci, 2010 Feb. PMID 19482445
  3. Immunostaining of the androgen receptor and sequence analysis of its DNA-binding domain in canine prostate cancer. Lai CL, et al. Vet J, 2009 Sep. PMID 18583166
  4. Age-dependent expression of 5alpha-reductase and androgen receptors mRNA by the canine prostate. Shidaifat F. Physiol Res, 2009. PMID 18198998
  5. Molecular cloning and functional characterization of the canine androgen receptor. Lu B, et al. Mol Cell Biochem, 2001 Oct. PMID 11768233

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polymorphisms were found in MAMLD1 (3 SNPs), SRD5A2 (5 SNPs), and AR (2 STRs and 1 SNP), while SRY was monomorphic.
    Title: Polymorphisms of MAMLD1, SRD5A2, and AR Candidate Genes in Seven Dogs (78,XY; SRY-Positive) Affected by Hypospadias or Cryptorchidism.
  2. Androgen-receptor-negative canine prostate cancer is a complex disease characterized by high genomic instability, showing a set of genes with similar alterations to human cancer.
    Title: Comprehensive Genomic Profiling of Androgen-Receptor-Negative Canine Prostate Cancer.
  3. the effects of REIC/Dkk-3 and small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) interactions on androgen receptor signaling in the canine androgen-independent prostate cancer cell line CHP-1
    Title: Canine REIC/Dkk-3 interacts with SGTA and restores androgen receptor signalling in androgen-independent prostate cancer cell lines.
  4. We concluded that sex steroid receptors and apoptotic proteins are differentially expressed in the follicles of adult dogs with polystic ovaries
    Title: Sex steroid receptors and apoptosis-related proteins are differentially expressed in polycystic ovaries of adult dogs.
  5. None of the detected polymorphisms, including variability of the CAG tandem repeats, could be related with the intersexual phenotype of the studied dogs.
    Title: Variability of CAG tandem repeats in exon 1 of the androgen receptor gene is not related with dog intersexuality.
  6. Androgen receptor staining was observed in most tumors from intact and castrated dogs, but the proportion of positive cells and the staining intensity were much lower than in the prostate of healthy, non-castrated dogs.
    Title: Immunostaining of the androgen receptor and sequence analysis of its DNA-binding domain in canine prostate cancer.
  7. AR, ER alpha, and ER beta are differently expressed in canine prostate tissue
    Title: Immunolocalization of androgen receptors, estrogen alpha receptors, and estrogen beta receptors in experimentally induced canine prostatic hyperplasia.
  8. Report age-dependent expression of 5alpha-reductase and androgen receptors mRNA by the canine prostate.
    Title: Age-dependent expression of 5alpha-reductase and androgen receptors mRNA by the canine prostate.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in androgen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
androgen receptor
Names
androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)
canine androgen receptor
dihydrotestosterone receptor
nuclear receptor subfamily 3 group C member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419301.1 → NP_001406230.1  androgen receptor

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000175
    UniProtKB/TrEMBL
    A0A8I3PZ26, A0A8P0NHX1

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051843.1 Reference ROS_Cfam_1.0

    Range
    52938974..53121719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038450180.1 → XP_038306108.1  androgen receptor

    Related
    ENSCAFP00845038896.1, ENSCAFT00845049586.1
    Conserved Domains (3) summary
    cd07073
    Location:661 → 906
    NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
    cd07173
    Location:543 → 624
    NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
    pfam02166
    Location:6 → 449
    Androgen_recep; Androgen receptor

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049299.1 Alternate UMICH_Zoey_3.1

    Range
    50910919..51093566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038523625.1 → XP_038379553.1  androgen receptor

    Conserved Domains (3) summary
    cd07073
    Location:660 → 905
    NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
    cd07173
    Location:542 → 623
    NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
    pfam02166
    Location:6 → 448
    Androgen_recep; Androgen receptor

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

    Range
    52242285..52424949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038652120.1 → XP_038508048.1  androgen receptor

    Conserved Domains (3) summary
    cd07073
    Location:661 → 906
    NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
    cd07173
    Location:543 → 624
    NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
    pfam02166
    Location:6 → 449
    Androgen_recep; Androgen receptor

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

    Range
    52163183..52345868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038587597.1 → XP_038443525.1  androgen receptor

    UniProtKB/TrEMBL
    A0A8C0TD12, A0A8I3PZ26, A0A8P0NHX1, F1P7L6
    Conserved Domains (3) summary
    cd07073
    Location:661 → 906
    NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
    cd07173
    Location:543 → 624
    NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
    pfam02166
    Location:6 → 449
    Androgen_recep; Androgen receptor

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    42802440..42991502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038464610.1 → XP_038320538.1  androgen receptor

    Conserved Domains (3) summary
    cd07073
    Location:661 → 906
    NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
    cd07173
    Location:543 → 624
    NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
    pfam02166
    Location:6 → 449
    Androgen_recep; Androgen receptor

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003053.1: Suppressed sequence

    Description
    NM_001003053.1: This RefSeq is a chimera.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TT90.1 GenPept UniProtKB/Swiss-Prot:Q9TT90

Gene LinkOut

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Research Materials
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