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IL6ST interleukin 6 cytokine family signal transducer [ Canis lupus familiaris (dog) ]

Gene ID: 403545, updated on 5-Mar-2024

Summary

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Official Symbol
IL6STprovided by VGNC
Official Full Name
interleukin 6 cytokine family signal transducerprovided by VGNC
Primary source
VGNC:VGNC:41994
See related
Ensembl:ENSCAFG00845028368
Gene type
protein coding
RefSeq status
INFERRED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
gp130
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (43679923..43738936, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (40260413..40306615, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (42380727..42426940, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (40758131..40804315, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (41560510..41606926, complement)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene interleukin 31 receptor A Neighboring gene 60S ribosomal protein L19-like Neighboring gene uncharacterized LOC608007 Neighboring gene uncharacterized LOC111092266

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cardiotrophin-1 stimulates endothelin-1 via gp130 in vascular endothelial cells. Jougasaki M, et al. Peptides, 2002 Aug. PMID 12182945
  2. Polarity and lipid raft association of the components of the ciliary neurotrophic factor receptor complex in Madin-Darby canine kidney cells. Buk DM, et al. J Cell Sci, 2004 Apr 15. PMID 15054106
  3. Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage. Onda H, et al. J Cereb Blood Flow Metab, 1999 Nov. PMID 10566975

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. each subunit of the CNTF receptor complex has a distinct distribution in polarised cells which may reflect the different roles the respective cytokines play in vivo
    Title: Polarity and lipid raft association of the components of the ciliary neurotrophic factor receptor complex in Madin-Darby canine kidney cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of CRLF-CLCF1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-6 receptor subunit beta
Names
glycoprotein 130
interleukin 6 signal transducer (gp130, oncostatin M receptor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287021.1 → NP_001273950.1  interleukin-6 receptor subunit beta precursor

    Status: INFERRED

    Source sequence(s)
    JAAUVH010000373
    UniProtKB/TrEMBL
    A0A8I3Q3U4, A0A8I3QGG4, A0A8P0P172, A0A8P0PBN4
    Conserved Domains (4) summary
    smart00060
    Location:519 → 599
    FN3; Fibronectin type 3 domain
    cd00063
    Location:222 → 321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:121 → 215
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    43679923..43738936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038657710.1 → XP_038513638.1  interleukin-6 receptor subunit beta isoform X3

    UniProtKB/TrEMBL
    A0A8C0PU01
    Conserved Domains (4) summary
    smart00060
    Location:519 → 599
    FN3; Fibronectin type 3 domain
    cd00063
    Location:222 → 321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:121 → 215
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_038657708.1 → XP_038513636.1  interleukin-6 receptor subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A8I3Q3U4, A0A8I3QGG4, A0A8P0P172, A0A8P0PBN4
    Related
    ENSCAFP00845039416.1, ENSCAFT00845050280.1
    Conserved Domains (4) summary
    smart00060
    Location:519 → 599
    FN3; Fibronectin type 3 domain
    cd00063
    Location:222 → 321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:121 → 215
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_038657709.1 → XP_038513637.1  interleukin-6 receptor subunit beta isoform X2

    UniProtKB/TrEMBL
    A0A8C0PU01, A0A8P0N9F5
    Related
    ENSCAFP00845039450.1, ENSCAFT00845050320.1
    Conserved Domains (4) summary
    smart00060
    Location:519 → 599
    FN3; Fibronectin type 3 domain
    cd00063
    Location:222 → 321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:121 → 215
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. XM_038657707.1 → XP_038513635.1  interleukin-6 receptor subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A8I3Q3U4, A0A8I3QGG4, A0A8P0P172, A0A8P0PBN4
    Related
    ENSCAFP00845039320.1, ENSCAFT00845050148.1
    Conserved Domains (4) summary
    smart00060
    Location:519 → 599
    FN3; Fibronectin type 3 domain
    cd00063
    Location:222 → 321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:121 → 215
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. XM_038657711.1 → XP_038513639.1  interleukin-6 receptor subunit beta isoform X4

    Conserved Domains (1) summary
    smart00060
    Location:229 → 309
    FN3; Fibronectin type 3 domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    40758131..40804315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    41560510..41606926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    42380727..42426940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    40260413..40306615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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