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PTGS1 prostaglandin-endoperoxide synthase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 403544, updated on 5-Mar-2024

Summary

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Official Symbol
PTGS1provided by VGNC
Official Full Name
prostaglandin-endoperoxide synthase 1provided by VGNC
Primary source
VGNC:VGNC:45151
See related
Ensembl:ENSCAFG00845013501
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
COX1; COX-1; COX-3; PGHS-1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (61110468..61132351, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (59390579..59412227, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (60289919..60311671, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (59884516..59906289, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (60200281..60222098, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily L member 11, pseudogene Neighboring gene ATP synthase subunit gamma, mitochondrial-like Neighboring gene uncharacterized LOC119873380 Neighboring gene uncharacterized LOC119873381

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. COX-1 and COX-2 expression in canine cutaneous, oral and ocular melanocytic tumours. Pires I, et al. J Comp Pathol, 2010 Aug-Oct. PMID 20207364
  2. Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis. Hong TT, et al. Am J Physiol Heart Circ Physiol, 2008 Jan. PMID 17921331
  3. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Chandrasekharan NV, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12242329, Free PMC Article
  4. Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. Lascelles BD, et al. J Orthop Res, 2009 Sep. PMID 19274754
  5. Genome sequence, comparative analysis and haplotype structure of the domestic dog. Lindblad-Toh K, et al. Nature, 2005 Dec 8. PMID 16341006

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. COX-1 expression did not differ significantly between benign and malignant skin lesions, but COX-2 expression was significantly greater in cutaneous malignant melanoma compared with melanocytoma (P=0.047).
    Title: COX-1 and COX-2 expression in canine cutaneous, oral and ocular melanocytic tumours.
  2. There was no significant difference in COX-1 or LOX protein in hip osteoarthritis joints
    Title: Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis.
  3. Endothelial constitutive COX-1 and the inducible vascular COX-2 serve important functions in maintaining vascular homeostasis.
    Title: Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables prostaglandin-endoperoxide synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cyclooxygenase pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
prostaglandin G/H synthase 1
Names
Cyclooxygenase-1
PGH synthase 1
PHS 1
Prostaglandin H2 synthase 1
cyclooxygenase
NP_001003023.1
XP_038530854.1
XP_038530855.1
XP_038530856.1
XP_038530857.1
XP_038530858.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003023.2 → NP_001003023.1  prostaglandin G/H synthase 1

    See identical proteins and their annotated locations for NP_001003023.1

    Status: PROVISIONAL

    Source sequence(s)
    AF535138
    UniProtKB/TrEMBL
    A0A8C0M635, A0A8I3NTG8
    Related
    ENSCAFP00845019189.1, ENSCAFT00845024410.1
    Conserved Domains (2) summary
    cd09816
    Location:123 → 609
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:66 → 103
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    61110468..61132351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038674926.1 → XP_038530854.1  prostaglandin G/H synthase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KR96
    Conserved Domains (1) summary
    cd09816
    Location:2 → 472
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

  2. XM_038674929.1 → XP_038530857.1  prostaglandin G/H synthase 1 isoform X4

    UniProtKB/Swiss-Prot
    F1PBX3, Q8HZR0, Q8HZR1
    Related
    ENSCAFP00845018920.1, ENSCAFT00845024089.1
    Conserved Domains (2) summary
    cd09816
    Location:93 → 585
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:36 → 73
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  3. XM_038674928.1 → XP_038530856.1  prostaglandin G/H synthase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I3NTG8
    Conserved Domains (2) summary
    cd09816
    Location:123 → 615
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:66 → 103
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  4. XM_038674930.1 → XP_038530858.1  prostaglandin G/H synthase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0Q9L9, A0A8P0TAE2
    Conserved Domains (2) summary
    cd09816
    Location:60 → 552
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:4 → 40
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  5. XM_038674927.1 → XP_038530855.1  prostaglandin G/H synthase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KR96
    Conserved Domains (1) summary
    cd09816
    Location:2 → 466
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    59884516..59906289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    60200281..60222098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    60289919..60311671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    59390579..59412227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8HZR1.2 GenPept UniProtKB/Swiss-Prot:Q8HZR1

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