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PPP3CA protein phosphatase 3 catalytic subunit alpha [ Canis lupus familiaris (dog) ]

Gene ID: 403486, updated on 5-Mar-2024

Summary

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Official Symbol
PPP3CAprovided by VGNC
Official Full Name
protein phosphatase 3 catalytic subunit alphaprovided by VGNC
Primary source
VGNC:VGNC:44918
See related
Ensembl:ENSCAFG00845024635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 32
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 32 NC_051836.1 (22910701..23219264, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 32 NC_006614.4 (18960549..19234052)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 32 NC_049253.1 (16885817..17195548)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 32 NC_049292.1 (22888729..23197885, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 32 NC_049773.1 (22670376..22979752, complement)

Chromosome 32 - NC_051836.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102153771 Neighboring gene uncharacterized LOC119867159 Neighboring gene uncharacterized LOC106558128 Neighboring gene glutathione S-transferase P-like Neighboring gene uncharacterized LOC119867193 Neighboring gene uncharacterized LOC119867160 Neighboring gene uncharacterized LOC102153933

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of calcineurin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein phosphatase 3 catalytic subunit alpha; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Names
calcineurin catalytic subunit
NP_001184025.1
XP_038299701.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197096.1 → NP_001184025.1  protein phosphatase 3 catalytic subunit alpha

    See identical proteins and their annotated locations for NP_001184025.1

    Status: VALIDATED

    Source sequence(s)
    AAEX03016788
    UniProtKB/TrEMBL
    A0A8C0P395, A0A8I3PMK3
    Related
    ENSCAFP00845034170.1, ENSCAFT00845043614.1
    Conserved Domains (1) summary
    cd07416
    Location:41 → 345
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051836.1 Reference ROS_Cfam_1.0

    Range
    22910701..23219264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038443773.1 → XP_038299701.1  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1

    UniProtKB/TrEMBL
    A0A8I3PS73
    Conserved Domains (1) summary
    cd07416
    Location:41 → 347
    MPP_PP2B; PP2B, metallophosphatase domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049292.1 Alternate UMICH_Zoey_3.1

    Range
    22888729..23197885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049773.1 Alternate UNSW_CanFamBas_1.0

    Range
    22670376..22979752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049253.1 Alternate UU_Cfam_GSD_1.0

    Range
    16885817..17195548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006614.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    18960549..19234052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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