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SPTAN1 spectrin alpha, non-erythrocytic 1 [ Canis lupus familiaris (dog) ]

Gene ID: 403484, updated on 5-Mar-2024

Summary

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Official Symbol
SPTAN1provided by VGNC
Official Full Name
spectrin alpha, non-erythrocytic 1provided by VGNC
Primary source
VGNC:VGNC:46773
See related
Ensembl:ENSCAFG00845027492
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See SPTAN1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
59
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (55876077..55937766, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (54149445..54211133, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (55041985..55103647, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (54635563..54694357, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (54949366..55011369, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene protein kinase N3 Neighboring gene SET nuclear proto-oncogene Neighboring gene dynein 2 intermediate chain 2 Neighboring gene U4 spliceosomal RNA Neighboring gene GLE1 RNA export mediator Neighboring gene U2 spliceosomal RNA Neighboring gene outer dense fiber of sperm tails 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of a polymorphic canine genetic marker which maps to human chromosome 9. Hershfield B, et al. Anim Genet, 1993 Aug. PMID 7916582

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
spectrin alpha chain, non-erythrocytic 1; LOW QUALITY PROTEIN: spectrin alpha chain, non-erythrocytic 1
Names
cardiomyocyte alpha-spectrin
sequence with a GC signal
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    55876077..55937766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038678405.1 → XP_038534333.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0SDA4, A0A8I3Q1F4, A0A8P0SP17
    Related
    ENSCAFP00845038137.1, ENSCAFT00845048617.1
    Conserved Domains (5) summary
    cd11808
    Location:971 → 1023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2353 → 2421
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679 → 890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1663 → 1767
    Spectrin; Spectrin repeat
    pfam08726
    Location:2428 → 2496
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  2. XM_038678412.1 → XP_038534340.1  spectrin alpha chain, non-erythrocytic 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I3PZ27
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2319 → 2387
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1650 → 1754
    Spectrin; Spectrin repeat
    pfam08726
    Location:2394 → 2462
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  3. XM_038678411.1 → XP_038534339.1  spectrin alpha chain, non-erythrocytic 1 isoform X9

    UniProtKB/TrEMBL
    A0A8I3PZ27
    Related
    ENSCAFP00845038545.1, ENSCAFT00845049128.1
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2324 → 2392
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1655 → 1759
    Spectrin; Spectrin repeat
    pfam08726
    Location:2399 → 2467
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  4. XM_038678407.1 → XP_038534335.1  spectrin alpha chain, non-erythrocytic 1 isoform X5

    UniProtKB/TrEMBL
    A0A8P0T000
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2345 → 2413
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1655 → 1759
    Spectrin; Spectrin repeat
    pfam08726
    Location:2420 → 2488
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  5. XM_038678406.1 → XP_038534334.1  spectrin alpha chain, non-erythrocytic 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0SDA4
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2349 → 2417
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1659 → 1763
    Spectrin; Spectrin repeat
    pfam08726
    Location:2424 → 2492
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  6. XM_038678409.1 → XP_038534337.1  spectrin alpha chain, non-erythrocytic 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I3S6F7
    Related
    ENSCAFP00845038409.1, ENSCAFT00845048962.1
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2339 → 2407
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1670 → 1774
    Spectrin; Spectrin repeat
    pfam08726
    Location:2414 → 2482
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  7. XM_038678404.1 → XP_038534332.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

    UniProtKB/TrEMBL
    A0A8P0P6P9
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2360 → 2428
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1670 → 1774
    Spectrin; Spectrin repeat
    pfam08726
    Location:2435 → 2503
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  8. XM_038678410.1 → XP_038534338.1  spectrin alpha chain, non-erythrocytic 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I3Q2G6, A0A8P0NRA5
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2338 → 2406
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1675 → 1779
    Spectrin; Spectrin repeat
    pfam08726
    Location:2413 → 2481
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  9. XM_038678403.1 → XP_038534331.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SDA4
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2365 → 2433
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1675 → 1779
    Spectrin; Spectrin repeat
    pfam08726
    Location:2440 → 2508
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  10. XM_038678408.1 → XP_038534336.1  spectrin alpha chain, non-erythrocytic 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I3Q2G6, A0A8P0NRA5
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2344 → 2412
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1675 → 1779
    Spectrin; Spectrin repeat
    pfam08726
    Location:2419 → 2487
    EFhand_Ca_insen; Ca2+ insensitive EF hand

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    54635563..54694357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038487237.1 → XP_038343165.1  LOW QUALITY PROTEIN: spectrin alpha chain, non-erythrocytic 1 isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    54949366..55011369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038613103.1 → XP_038469031.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

    Conserved Domains (5) summary
    cd11808
    Location:971 → 1023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2353 → 2421
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679 → 890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1663 → 1767
    Spectrin; Spectrin repeat
    pfam08726
    Location:2428 → 2496
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  2. XM_038613111.1 → XP_038469039.1  spectrin alpha chain, non-erythrocytic 1 isoform X10

    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2319 → 2387
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1650 → 1754
    Spectrin; Spectrin repeat
    pfam08726
    Location:2394 → 2462
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  3. XM_038613110.1 → XP_038469038.1  spectrin alpha chain, non-erythrocytic 1 isoform X9

    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2324 → 2392
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1655 → 1759
    Spectrin; Spectrin repeat
    pfam08726
    Location:2399 → 2467
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  4. XM_038613106.1 → XP_038469034.1  spectrin alpha chain, non-erythrocytic 1 isoform X5

    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2345 → 2413
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1655 → 1759
    Spectrin; Spectrin repeat
    pfam08726
    Location:2420 → 2488
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  5. XM_038613104.1 → XP_038469032.1  spectrin alpha chain, non-erythrocytic 1 isoform X4

    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2349 → 2417
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1659 → 1763
    Spectrin; Spectrin repeat
    pfam08726
    Location:2424 → 2492
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  6. XM_038613108.1 → XP_038469036.1  spectrin alpha chain, non-erythrocytic 1 isoform X7

    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2339 → 2407
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1670 → 1774
    Spectrin; Spectrin repeat
    pfam08726
    Location:2414 → 2482
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  7. XM_038613102.1 → XP_038469030.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2360 → 2428
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1670 → 1774
    Spectrin; Spectrin repeat
    pfam08726
    Location:2435 → 2503
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  8. XM_038613109.1 → XP_038469037.1  spectrin alpha chain, non-erythrocytic 1 isoform X8

    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2338 → 2406
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1675 → 1779
    Spectrin; Spectrin repeat
    pfam08726
    Location:2413 → 2481
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  9. XM_038613101.1 → XP_038469029.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2365 → 2433
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1675 → 1779
    Spectrin; Spectrin repeat
    pfam08726
    Location:2440 → 2508
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  10. XM_038613107.1 → XP_038469035.1  spectrin alpha chain, non-erythrocytic 1 isoform X6

    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2344 → 2412
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1675 → 1779
    Spectrin; Spectrin repeat
    pfam08726
    Location:2419 → 2487
    EFhand_Ca_insen; Ca2+ insensitive EF hand

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    55041985..55103647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038549160.1 → XP_038405088.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0SDA4, A0A8I3Q1F4, A0A8P0SP17
    Conserved Domains (5) summary
    cd11808
    Location:971 → 1023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2353 → 2421
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679 → 890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1663 → 1767
    Spectrin; Spectrin repeat
    pfam08726
    Location:2428 → 2496
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  2. XM_038549167.1 → XP_038405095.1  spectrin alpha chain, non-erythrocytic 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I3PZ27
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2319 → 2387
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1650 → 1754
    Spectrin; Spectrin repeat
    pfam08726
    Location:2394 → 2462
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  3. XM_038549166.1 → XP_038405094.1  spectrin alpha chain, non-erythrocytic 1 isoform X9

    UniProtKB/TrEMBL
    A0A8I3PZ27
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2324 → 2392
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1655 → 1759
    Spectrin; Spectrin repeat
    pfam08726
    Location:2399 → 2467
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  4. XM_038549162.1 → XP_038405090.1  spectrin alpha chain, non-erythrocytic 1 isoform X5

    UniProtKB/TrEMBL
    A0A8P0T000
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2345 → 2413
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1655 → 1759
    Spectrin; Spectrin repeat
    pfam08726
    Location:2420 → 2488
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  5. XM_038549161.1 → XP_038405089.1  spectrin alpha chain, non-erythrocytic 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0SDA4
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2349 → 2417
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1659 → 1763
    Spectrin; Spectrin repeat
    pfam08726
    Location:2424 → 2492
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  6. XM_038549164.1 → XP_038405092.1  spectrin alpha chain, non-erythrocytic 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I3S6F7
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2339 → 2407
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1670 → 1774
    Spectrin; Spectrin repeat
    pfam08726
    Location:2414 → 2482
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  7. XM_038549159.1 → XP_038405087.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

    UniProtKB/TrEMBL
    A0A8P0P6P9
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2360 → 2428
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1670 → 1774
    Spectrin; Spectrin repeat
    pfam08726
    Location:2435 → 2503
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  8. XM_038549165.1 → XP_038405093.1  spectrin alpha chain, non-erythrocytic 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I3Q2G6, A0A8P0NRA5
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2338 → 2406
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1675 → 1779
    Spectrin; Spectrin repeat
    pfam08726
    Location:2413 → 2481
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  9. XM_038549158.1 → XP_038405086.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SDA4
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2365 → 2433
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1675 → 1779
    Spectrin; Spectrin repeat
    pfam08726
    Location:2440 → 2508
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  10. XM_038549163.1 → XP_038405091.1  spectrin alpha chain, non-erythrocytic 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I3Q2G6, A0A8P0NRA5
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2344 → 2412
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1675 → 1779
    Spectrin; Spectrin repeat
    pfam08726
    Location:2419 → 2487
    EFhand_Ca_insen; Ca2+ insensitive EF hand

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    54149445..54211133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_537823.7 → XP_537823.4  spectrin alpha chain, non-erythrocytic 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0SDA4, A0A8I3Q1F4, A0A8P0SP17
    Conserved Domains (5) summary
    cd11808
    Location:971 → 1023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2353 → 2421
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679 → 890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1663 → 1767
    Spectrin; Spectrin repeat
    pfam08726
    Location:2428 → 2496
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  2. XM_005625287.4 → XP_005625344.1  spectrin alpha chain, non-erythrocytic 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I3PZ27
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2319 → 2387
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1650 → 1754
    Spectrin; Spectrin repeat
    pfam08726
    Location:2394 → 2462
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  3. XM_005625286.4 → XP_005625343.1  spectrin alpha chain, non-erythrocytic 1 isoform X9

    UniProtKB/TrEMBL
    A0A8I3PZ27
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2324 → 2392
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1655 → 1759
    Spectrin; Spectrin repeat
    pfam08726
    Location:2399 → 2467
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  4. XM_005625283.4 → XP_005625340.1  spectrin alpha chain, non-erythrocytic 1 isoform X5

    UniProtKB/TrEMBL
    A0A8P0T000
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2345 → 2413
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1655 → 1759
    Spectrin; Spectrin repeat
    pfam08726
    Location:2420 → 2488
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  5. XM_014117013.3 → XP_013972488.1  spectrin alpha chain, non-erythrocytic 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0SDA4
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2349 → 2417
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1659 → 1763
    Spectrin; Spectrin repeat
    pfam08726
    Location:2424 → 2492
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  6. XM_005625285.4 → XP_005625342.1  spectrin alpha chain, non-erythrocytic 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I3S6F7
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2339 → 2407
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1670 → 1774
    Spectrin; Spectrin repeat
    pfam08726
    Location:2414 → 2482
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  7. XM_005625282.4 → XP_005625339.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

    UniProtKB/TrEMBL
    A0A8P0P6P9
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2360 → 2428
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1670 → 1774
    Spectrin; Spectrin repeat
    pfam08726
    Location:2435 → 2503
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  8. XM_014117014.3 → XP_013972489.1  spectrin alpha chain, non-erythrocytic 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I3Q2G6, A0A8P0NRA5
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2338 → 2406
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1675 → 1779
    Spectrin; Spectrin repeat
    pfam08726
    Location:2413 → 2481
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  9. XM_038617897.1 → XP_038473825.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SDA4
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2365 → 2433
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1675 → 1779
    Spectrin; Spectrin repeat
    pfam08726
    Location:2440 → 2508
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  10. XM_005625284.4 → XP_005625341.1  spectrin alpha chain, non-erythrocytic 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I3Q2G6, A0A8P0NRA5
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2344 → 2412
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1675 → 1779
    Spectrin; Spectrin repeat
    pfam08726
    Location:2419 → 2487
    EFhand_Ca_insen; Ca2+ insensitive EF hand
Nucleotide Protein Strain
Heading Accession and Version

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