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NR1I2 nuclear receptor subfamily 1 group I member 2 [ Canis lupus familiaris (dog) ]

Gene ID: 403482, updated on 5-Mar-2024

Summary

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Official Symbol
NR1I2provided by VGNC
Official Full Name
nuclear receptor subfamily 1 group I member 2provided by VGNC
Primary source
VGNC:VGNC:53079
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
PXR
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 33
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 33 NC_051837.1 (23682177..23694192)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 33 NC_006615.4 (23474457..23486487)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 33 NC_049293.1 (23486165..23498350)

Chromosome 33 - NC_051837.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 91 Neighboring gene methylsterol monooxygenase 1-like Neighboring gene uncharacterized LOC106558176 Neighboring gene 60S ribosomal protein L27a-like Neighboring gene glycogen synthase kinase 3 beta Neighboring gene small nucleolar RNA U3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation. Pinne M, et al. PLoS One, 2016. PMID 27732639, Free PMC Article
  2. Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Moore LB, et al. Mol Endocrinol, 2002 May. PMID 11981033

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
nuclear receptor subfamily 1 group I member 2
Names
pregnane X receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051837.1 Reference ROS_Cfam_1.0

    Range
    23682177..23694192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038445374.1 → XP_038301302.1  nuclear receptor subfamily 1 group I member 2 isoform X1

    Conserved Domains (2) summary
    cd06934
    Location:524 → 809
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cl02596
    Location:411 → 508
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049293.1 Alternate UMICH_Zoey_3.1

    Range
    23486165..23498350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038519634.1 → XP_038375562.1  nuclear receptor subfamily 1 group I member 2 isoform X2

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006615.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    23474457..23486487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038462516.1 → XP_038318444.1  nuclear receptor subfamily 1 group I member 2 isoform X3

    Conserved Domains (2) summary
    cd06934
    Location:552 → 837
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cl02596
    Location:439 → 536
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
Nucleotide Protein Strain
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