U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AcCoAS Acetyl Coenzyme A synthase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40348, updated on 26-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
AcCoASprovided by FlyBase
Official Full Name
Acetyl Coenzyme A synthaseprovided by FlyBase
Primary source
FLYBASE:FBgn0012034
Locus tag
Dmel_CG9390
See related
AllianceGenome:FB:FBgn0012034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AcCoAs; ACeCS1; acs; ACS; BEST:GH28401; CG9390; dACS; Dmel\CG9390
Summary
Predicted to enable short-chain fatty acid-CoA ligase activity. Involved in behavioral response to ethanol. Is expressed in adult head. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
78C3-78C4; 3-47 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21270722..21280243, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21263822..21273343, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45162 Neighboring gene uncharacterized protein Neighboring gene pumpless Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolution of the AMP-forming acetyl-CoA synthetase gene in the Drosophilidae family. Karan D, et al. J Mol Evol, 2003. PMID 15008428
  2. DISCO Interacting Protein 2 regulates axonal bifurcation and guidance of Drosophila mushroom body neurons. Nitta Y, et al. Dev Biol, 2017 Jan 15. PMID 27908785
  3. The conserved microRNA miR-210 regulates lipid metabolism and photoreceptor maintenance in the Drosophila retina. Lyu J, et al. Cell Death Differ, 2021 Feb. PMID 32913227, Free PMC Article
  4. Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions. Inouye S. Cell Mol Life Sci, 2010 Feb. PMID 19859663
  5. Suppression of food intake and growth by amino acids in Drosophila: the role of pumpless, a fat body expressed gene with homology to vertebrate glycine cleavage system. Zinke I, et al. Development, 1999 Dec. PMID 10556053

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables AMP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables short-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acetyl-CoA biosynthetic process from acetate IEA
Inferred from Electronic Annotation
more info
  
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in photoreceptor cell maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
acetyl coenzyme A synthase
Names
Ac CoA synthase
AcCoA synthetase
AcCoAS-PA
AcCoAS-PB
AcCoAS-PD
Acetyl-CoA synthase
Acetyl-CoA sythase
AcetylCoA synthase
CG9390-PA
CG9390-PB
CG9390-PD
acetate-coenzyme A ligase
acetyl CoA synthase
acetyl CoA synthetase
acetyl-CoA synthetase
acetyl-coenzyme A synthase
NP_001014599.2
NP_524196.2
NP_730611.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21270722..21280243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168894.3 → NP_730611.1  acetyl coenzyme A synthase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730611.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24226, Q8IH30, Q9VP60, Q9VP61
    UniProtKB/TrEMBL
    F3YDG9, Q59E09
    Related
    FBpp0078067
    Conserved Domains (2) summary
    cd05966
    Location:30 → 654
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
    PRK00174
    Location:7 → 665
    PRK00174; acetyl-CoA synthetase; Provisional

  2. NM_001014599.2 → NP_001014599.2  acetyl coenzyme A synthase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014599.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24226, Q8IH30, Q9VP60, Q9VP61
    UniProtKB/TrEMBL
    F3YDG9, Q59E09
    Conserved Domains (2) summary
    cd05966
    Location:30 → 654
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
    PRK00174
    Location:7 → 665
    PRK00174; acetyl-CoA synthetase; Provisional

  3. NM_079472.3 → NP_524196.2  acetyl coenzyme A synthase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524196.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VP61
    Related
    FBpp0078068
    Conserved Domains (2) summary
    cd05966
    Location:1 → 508
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
    PLN03051
    Location:1 → 491
    PLN03051; acyl-activating enzyme; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q59E09 Q59E09
Q9VP61.1 Q9VP61

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous