MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) [Canis lupus familiaris (dog)] - Gene

Summary

Gene symbol: MMP3
Gene description: matrix metallopeptidase 3 (stromelysin 1, progelatinase)
See related: Ensembl:ENSCAFG00845000842
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	5	NC_051809.1 (29000797..29009079)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	5	NC_006587.4 (28898123..28906399)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	5	NC_049226.1 (29090249..29098533)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	5	NC_049265.1 (29035847..29044131)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	5	NC_049746.1 (28915267..28923546)

Chromosome 5 - NC_051809.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings suggested that increased TGF-beta3 and MMP-3 contribute to the pathogenesis of valvular degeneration associated with chronic mitral valve disease.
Title: Effects of transforming growth factor-β3 and matrix metalloproteinase-3 on the pathogenesis of chronic mitral valvular disease in dogs.
Both mRNA transcript levels and the activities of MMP-3 and MMP-7 are elevated in X-linked Alport syndrome (XLAS) kidneys from dogs.
Title: Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: stromelysin-1

Names: MMP-3; SL-1; matrix metalloproteinase-3

NP_001002967.1

EC 3.4.24.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002967.1 → NP_001002967.1 stromelysin-1 precursor

See identical proteins and their annotated locations for NP_001002967.1

Status: PROVISIONAL

Source sequence(s)

AY183143

UniProtKB/Swiss-Prot

Q6Y4Q5

UniProtKB/TrEMBL

A0A8C0K9E2

Related

ENSCAFP00845001083.1, ENSCAFT00845001397.1

Conserved Domains (3) summary

cd00094
Location:288 → 478

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:108 → 264

Peptidase_M10; Matrixin

pfam01471
Location:35 → 87

PG_binding_1; Putative peptidoglycan binding domain