CDKN1B cyclin dependent kinase inhibitor 1B [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: CDKN1Bprovided by VGNC
Official Full Name: cyclin dependent kinase inhibitor 1Bprovided by VGNC
Primary source: VGNC:VGNC:39069
See related: Ensembl:ENSCAFG00845023770
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: p27; Kip1; p27Kip1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 27

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	27	NC_051831.1 (33916284..33921570, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	27	NC_006609.4 (12832036..12833182)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	27	NC_049248.1 (12566389..12567535)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	27	NC_049287.1 (33812098..33813242, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	27	NC_049768.1 (33762117..33763263, complement)

Chromosome 27 - NC_051831.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serum starvation and TdR methods could achieve sufficient synchronization of CHMm cells. Moreover, the expression of p27, p53 and bcl-2 genes was related to cyclical movements and apoptosis.
Title: Serum starvation and thymidine double blocking achieved efficient cell cycle synchronization and altered the expression of p27, p53, bcl-2 in canine breast cancer cells.
serine 123 phosphorylation modulates p21 protein stability and activity by suppressing ubiquitin-independent proteasomal degradation.
Title: Serine 123 phosphorylation modulates p21 protein stability and activity by suppressing ubiquitin-independent proteasomal degradation.
expression of Ki-67, PCNA and p27kip1 in corticotroph adenomas in enlarged and non-enlarged pituitaries; no significant differences in Ki-67, PCNA, and p27kip1 labeling indices were found between enlarged and non-enlarged pituitaries
Title: Expression of Ki-67, PCNA, and p27kip1 in canine pituitary corticotroph adenomas.
Taken together the results suggest that loss of p21 overexpression is associated with tumor metastasis while reduced cell cycle inhibition by p27 is associated with malignant progression.
Title: Differential expression of cell cycle regulators p21, p27 and p53 in metastasizing canine mammary adenocarcinomas versus normal mammary glands.
This study found that nuclear p27 acts as a cyclin-dependent kinase (CDK) inhibitor in canine skin neoplasms and nuclear p21 expression is involved in the induction of epithelial differentiation and seems to be unrelated to CDK inhibition.
Title: Immunohistochemical detection of p27 and p21 proteins in canine hair follicle and epidermal neoplasms.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cyclin-dependent kinase inhibitor 1B

Names: putative cyclin-dependent kinase inhibitor p27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002957.2 → NP_001002957.2 cyclin-dependent kinase inhibitor 1B

Status: VALIDATED

Source sequence(s)

JAAUVH010000362

UniProtKB/TrEMBL

A0A8C0K074, A0A8C0NMF9, F1PGU6, Q68V02

Conserved Domains (1) summary

pfam02234
Location:32 → 77

CDI; Cyclin-dependent kinase inhibitor

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051831.1 Reference ROS_Cfam_1.0

Range

33916284..33921570 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038437725.1 → XP_038293653.1 cyclin-dependent kinase inhibitor 1B isoform X1

UniProtKB/TrEMBL

A0A8C0K074, A0A8C0NMF9, F1PGU6, Q68V02

Related

ENSCAFP00845032915.1, ENSCAFT00845041967.1

Conserved Domains (1) summary

pfam02234
Location:32 → 77

CDI; Cyclin-dependent kinase inhibitor