PLAU plasminogen activator, urokinase [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PLAUprovided by VGNC
Official Full Name: plasminogen activator, urokinaseprovided by VGNC
Primary source: VGNC:VGNC:52017
See related: Ensembl:ENSCAFG00845008986
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	4	NC_051808.1 (24609212..24613966)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	4	NC_006586.4 (24466425..24471181)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	4	NC_049225.1 (25061896..25066649)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	4	NC_049264.1 (24506511..24511263)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	4	NC_049745.1 (24706941..24711694)

Chromosome 4 - NC_051808.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that uPA and uPAR play a significant role in the malignant proliferation of canine haemangiosarcoma
Title: Immunohistochemical Detection of Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor in Canine Vascular Endothelial Tumours.
The blood levels of urokinase-type plasminogen activator, tissue-type plasminogen activator, and matrix metalloproteinase-9 as markers of toxocariasis is reported.
Title: Changes to plasminogen activators and matrix metalloproteinase-9 in dogs with toxocarosis.

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General gene information

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Markers

PLAU (e-PCR), detects polymorphism
- UniSTS:266574

BARC0043 (e-PCR)
- UniSTS:255324

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in fibrinolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in plasminogen activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: urokinase-type plasminogen activator

NP_001181881.1

EC 3.4.21.73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001194952.1 → NP_001181881.1 urokinase-type plasminogen activator precursor

Status: VALIDATED

Source sequence(s)

AY455801, DN376076, DN382369, DN443940, JAAUVH010000355

UniProtKB/TrEMBL

A0A8C0KUG5, A0A8C0RW08, A0A8I3NA75

Related

ENSCAFP00845012311.1, ENSCAFT00845015828.1

Conserved Domains (2) summary

smart00130
Location:66 → 149

KR; Kringle domain

cd00190
Location:176 → 419

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...