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GJA1 gap junction protein alpha 1 [ Canis lupus familiaris (dog) ]

Gene ID: 403418, updated on 5-Mar-2024

Summary

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Official Symbol
GJA1provided by VGNC
Official Full Name
gap junction protein alpha 1provided by VGNC
Primary source
VGNC:VGNC:41231
See related
Ensembl:ENSCAFG00845009132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
cx43
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
2
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (61130176..61143784)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (61750272..61753194)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (61515138..61518103)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (61052769..61055708)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (60868101..60871024)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111096171 Neighboring gene TBC1 domain family member 32 Neighboring gene uncharacterized LOC102157283 Neighboring gene uncharacterized LOC119870673 Neighboring gene peptidyl-prolyl cis-trans isomerase A-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Connexin 43 reduces susceptibility to sympathetic atrial fibrillation. Luo B, et al. Int J Mol Med, 2018 Aug. PMID 29717772
  2. The involvement of gap junctions in the delayed phase of the protection induced by cardiac pacing in dogs. Gönczi M, et al. Clin Sci (Lond), 2012 Jul. PMID 22242938
  3. Myofibroblasts cause heterogeneous Cx43 reduction and are unlikely to be coupled to myocytes in the healing canine infarct. Baum JR, et al. Am J Physiol Heart Circ Physiol, 2012 Feb 1. PMID 22101526, Free PMC Article
  4. All-trans retinoic Acid regulates cx43 expression, gap junction communication and differentiation in primary lens epithelial cells. Long AC, et al. Curr Eye Res, 2010 Aug. PMID 20673043
  5. Gap junction heterogeneity as mechanism for electrophysiologically distinct properties across the ventricular wall. Strom M, et al. Am J Physiol Heart Circ Physiol, 2010 Mar. PMID 20035026, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gene and protein expression of connexins 37 and 43 in cumulus-oocytes complexes throughout the canine oestrous cycle.
    Title: Gene and protein expression of connexins 37 and 43 in cumulus-oocytes complexes throughout the canine oestrous cycle.
  2. The results of the present study suggest that Cx43 reduces susceptibility to atrial fibrillation.
    Title: Connexin 43 reduces susceptibility to sympathetic atrial fibrillation.
  3. increased acetylation of Cx43 in the left ventricles of dogs subjected to chronic tachypacing as abnormal ventricular activation... altered electrical activity can regulate cardiomyocyte communication by influencing the acetylation status of Cx43
    Title: Acetylation mediates Cx43 reduction caused by electrical stimulation.
  4. the alteration of Cx43 and/or phosphorylated Cx43 levels and the imbalance of MMP-2 and TIMP-2 may contribute to the initiation and/or persistence of ventricular fibrillation.
    Title: Dynamic alterations of connexin43, matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 during ventricular fibrillation in canine.
  5. Akt-dependent phosphorylation of Serine 373 increases gap junction size and communication by completely eliminating the interaction between Cx43 and ZO-1.
    Title: Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size.
  6. Cardiac pacing results in time-dependent changes in connexin43 expression, which may alter gap junction function and influence arrhythmia generation during a subsequent ischaemia/reperfusion insult.
    Title: The involvement of gap junctions in the delayed phase of the protection induced by cardiac pacing in dogs.
  7. An increase of myofibroblasts in the infarcted heart causes heterogeneous Cx43 levels, possibly as a result of the release of IL-1beta and decreased cell-cell communication, which leads to conduction abnormalities following infarction.
    Title: Myofibroblasts cause heterogeneous Cx43 reduction and are unlikely to be coupled to myocytes in the healing canine infarct.
  8. Cx43 ubiquitination is not necessary for the regulation of Cx43 turnover; rather, Akt activity, probably through direct phosphorylation of Cx43, controls gap junction stability.
    Title: Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stability.
  9. All-trans retinoic acid significantly increased Cx43 expression and gap junction intercellular communication in canine lens epithelial cells (LEC), associated with increased cell differentiation.
    Title: All-trans retinoic Acid regulates cx43 expression, gap junction communication and differentiation in primary lens epithelial cells.
  10. Connexin 43 gap junctions with highly variable morphology are formed between cardiomyocyte lateral membranes with increased frequency in heart failure and GJ turnover likely occurs via an autophagic pathway.
    Title: Ultrastructure and regulation of lateralized connexin43 in the failing heart.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of connexin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
gap junction alpha-1 protein
Names
gap junction protein, alpha 1, 43kDa (connexin 43)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002951.3 → NP_001002951.2  gap junction alpha-1 protein

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000354
    UniProtKB/Swiss-Prot
    Q6S9C0
    UniProtKB/TrEMBL
    A0A654IEC4, A0A8C0LBI4, A0A8P0T9K9
    Conserved Domains (2) summary
    pfam00029
    Location:3 → 233
    Connexin
    pfam03508
    Location:293 → 312
    Connexin43; Gap junction alpha-1 protein (Cx43)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    61130176..61143784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038653369.1 → XP_038509297.1  gap junction alpha-1 protein isoform X1

    UniProtKB/Swiss-Prot
    Q6S9C0
    UniProtKB/TrEMBL
    A0A654IEC4, A0A8C0LBI4, A0A8P0T9K9
    Related
    ENSCAFP00845012583.1, ENSCAFT00845016174.1
    Conserved Domains (2) summary
    pfam00029
    Location:3 → 233
    Connexin
    pfam03508
    Location:293 → 312
    Connexin43; Gap junction alpha-1 protein (Cx43)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    61052769..61055708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    60868101..60871024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    61515138..61518103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    61750272..61753194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6S9C0.3 GenPept UniProtKB/Swiss-Prot:Q6S9C0

Gene LinkOut

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