NGF nerve growth factor [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: NGFprovided by VGNC
Official Full Name: nerve growth factorprovided by VGNC
Primary source: VGNC:VGNC:54333
See related: Ensembl:ENSCAFG00845027859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: NGFB
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	17	NC_051821.1 (53781750..53834593, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	17	NC_006599.4 (52550068..52550845, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	17	NC_049238.1 (53428944..53429721, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	17	NC_049277.1 (52820833..52821610, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	17	NC_049758.1 (52855816..52856593, complement)

Chromosome 17 - NC_051821.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suggest that nerve growth factor, which is elevated in the failing human heart, causes hypertrophy of neurons in cardiac ganglia.
Title: Hypertrophy of neurons within cardiac ganglia in human, canine, and rat heart failure: the potential role of nerve growth factor.

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General gene information

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Markers

NGFB (e-PCR)
- UniSTS:503833

NGFB (e-PCR)
- UniSTS:278830

NGFB (e-PCR)
- UniSTS:264122

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables nerve growth factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in memory	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in nerve development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in nerve growth factor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuron projection morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of collateral sprouting	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: beta-nerve growth factor

Names: nerve growth factor beta; nerve growth factor, beta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001194950.1 → NP_001181879.1 beta-nerve growth factor precursor

Status: VALIDATED

Source sequence(s)

AJ626845, AY800386, JAAUVH010000359

UniProtKB/TrEMBL

A0A8C0L5D3, A0A8C0MBJ0, A0A8I3PYI3, Q531B0

Related

ENSCAFP00845038559.1, ENSCAFT00845049144.1

Conserved Domains (1) summary

pfam00243
Location:128 → 238

NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051821.1 Reference ROS_Cfam_1.0

Range

53781750..53834593 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038690419.1 → XP_038546347.1 beta-nerve growth factor isoform X1

UniProtKB/TrEMBL

A0A8C0L5D3, A0A8C0MBJ0, A0A8I3PYI3, Q531B0

Conserved Domains (1) summary

pfam00243
Location:128 → 238

NGF; Nerve growth factor family