tirap toll-interleukin 1 receptor (TIR) domain containing adaptor protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tirapprovided by ZNC
Official Full Name: toll-interleukin 1 receptor (TIR) domain containing adaptor proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040219-4
See related: AllianceGenome:ZFIN:ZDB-GENE-040219-4
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mal
Summary: Predicted to enable Toll-like receptor 2 binding activity and Toll-like receptor 4 binding activity. Predicted to be involved in several processes, including I-kappaB kinase/NF-kappaB signaling; positive regulation of cytokine production; and regulation of intracellular signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (48751608..48755948, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (48756825..48761160, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish Tirap adaptor lacks the phosphatidylinositol 4,5-bisphosphate binding motif, which could partially explain zebrafish insensitivity to lipopolysaccharide, hence its resulting inability to activate downstream Toll-like receptor signaling.
Title: A unique feature of Toll/IL-1 receptor domain-containing adaptor protein is partially responsible for lipopolysaccharide insensitivity in zebrafish with a highly conserved function of MyD88.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

ha2919 (e-PCR)
- UniSTS:515610

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Toll-like receptor 2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables Toll-like receptor 4 binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of tumor necrosis factor production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: toll/interleukin-1 receptor domain-containing adapter protein

Names: MyD88 adapter-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

48751608..48755948 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002667112.6 → XP_002667158.2 toll/interleukin-1 receptor domain-containing adapter protein isoform X2

UniProtKB/TrEMBL

A0A8M1REJ6

Conserved Domains (1) summary

pfam13676
Location:75 → 183

TIR_2; TIR domain
XM_017352088.2 → XP_017207577.1 toll/interleukin-1 receptor domain-containing adapter protein isoform X1

UniProtKB/TrEMBL

A0A8M6Z2S6