myd88 MYD88 innate immune signal transduction adaptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myd88provided by ZNC
Official Full Name: MYD88 innate immune signal transduction adaptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040219-3
See related: Ensembl:ENSDARG00000010169 AllianceGenome:ZFIN:ZDB-GENE-040219-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:103541
Summary: Predicted to enable Toll-like receptor binding activity. Acts upstream of or within several processes, including neutrophil chemotaxis; positive regulation of NIK/NF-kappaB signaling; and response to bacterium. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; hematopoietic system; pleuroperitoneal region; tail bud; and ventral fin fold. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia; colorectal carcinoma; and primary immunodeficiency disease. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (20188914..20192854, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (20044495..20048435, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The adapter protein Myd88 plays an important role in limiting mycobacterial growth in a zebrafish model for tuberculosis.
Title: The adapter protein Myd88 plays an important role in limiting mycobacterial growth in a zebrafish model for tuberculosis.
suppressed at the mRNA level by intestinal microbial colonization
Title: Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88.
microbiota-induced, Myd88-dependent signaling inhibits host Notch signaling in the intestinal epithelium, thereby promoting secretory cell fate determination
Title: Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling.
Fish IRF6 is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 and TBK1, suggesting that differences in the IRF6 regulation pattern exist between lower and higher vertebrates.
Title: Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways.
DrIRF1 works in concert with MyD88 to activate zebrafish IFNvarphi3 but not IFNvarphi1. These results provide insights into the evolving function of IRF1 as a positive IFN regulator.
Title: Zebrafish IRF1 regulates IFN antiviral response through binding to IFNϕ1 and IFNϕ3 promoters downstream of MyD88 signaling.
MyD88 signaling has an important protective role during early pathogenesis.
Title: Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system.
MyD88-dependent signaling is involved in the innate immune response of the developing zebrafish embryo, a model for the study of vertebrate innate immunity.
Title: MyD88 innate immune function in a zebrafish embryo infection model.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables TIR domain binding	IEA Inferred from Electronic Annotation more info
enables Toll-like receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within MyD88-dependent toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Toll signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within activation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monocyte activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to molecule of bacterial origin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myeloid differentiation primary response protein MyD88

Names: myeloid differentiation primary response 88; myeloid differentiation primary response factor 88; myeloid differentiation primary response gene (88); zMyD88

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212814.2 → NP_997979.2 myeloid differentiation primary response protein MyD88

See identical proteins and their annotated locations for NP_997979.2

Status: PROVISIONAL

Source sequence(s)

BC083419

UniProtKB/Swiss-Prot

Q45VT5, Q5XJ85, Q6TQG4, Q6TS40

UniProtKB/TrEMBL

B2GQ86

Related

ENSDARP00000020711.6, ENSDART00000011143.7

Conserved Domains (2) summary

smart00255
Location:148 → 284

TIR; Toll - interleukin 1 - resistance

cd08312
Location:21 → 98

Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88