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tlr8a toll-like receptor 8a [ Danio rerio (zebrafish) ]

Gene ID: 403137, updated on 4-Jan-2025

Summary

Official Symbol
tlr8aprovided by ZNC
Official Full Name
toll-like receptor 8aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040219-13
See related
Ensembl:ENSDARG00000090119 AllianceGenome:ZFIN:ZDB-GENE-040219-13
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
TIR8.2
Summary
Predicted to enable pattern recognition receptor activity. Predicted to be involved in several processes, including canonical NF-kappaB signal transduction; positive regulation of interleukin-6 production; and toll-like receptor signaling pathway. Predicted to act upstream of or within inflammatory response; innate immune response; and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in blood; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TLR8 (toll like receptor 8). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

See tlr8a in Genome Data Viewer
Location:
chromosome: Un
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_003336636.1 (6147..13421, complement)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003336636.1 (7459..13453, complement)

NW_003336636.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in canonical NF-kappaB signal transduction  
involved_in defense response to virus  
acts_upstream_of_or_within immune system process  
acts_upstream_of_or_within inflammatory response  
acts_upstream_of_or_within innate immune response  
involved_in positive regulation of interleukin-6 production  
involved_in regulation of macromolecule metabolic process  
acts_upstream_of_or_within signal transduction  
involved_in toll-like receptor signaling pathway  
Component Evidence Code Pubs
located_in membrane  
is_active_in plasma membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NW_003336636.1 Reference GRCz11 Primary Assembly

    Range
    6147..13421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001920559.7XP_001920594.5  toll-like receptor 8

    UniProtKB/TrEMBL
    A0A8M1QHF1
    Related
    ENSDARP00000107821.3, ENSDART00000124995.3
    Conserved Domains (6) summary
    smart00255
    Location:8581000
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:465487
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:692752
    LRR_8; Leucine rich repeat
    cl15307
    Location:750789
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl26018
    Location:15226
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:189702
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
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